摘要
目的 探讨抗结核治疗中乙肝病毒感染对肝功能的影响及其对策。方法 回顾性分析174 6例肺结核病人及其中 16 0例药物性肝损害的相关临床资料。结果 176例乙型肝炎病毒标志物(HBVM )阳性结核病人中有 6 8例 (38.6 % )出现肝损害 ,HBVM阴性患者 14 90例中出现肝损害 70例 (4.7% ) ,另有 80例未测HBVM者中 2 2例 (2 7.5 % )出现肝损害。HBVM阳性与阴性的肝损害发生率差异极显著 (P <0 .0 1)。在治疗过程中出现肝损时间多为 15～ 90d。结论 短程化疗中乙肝病毒感染对肝功能有一定的影响 ,在抗结核治疗前检查HBVM及肝功能十分必要 ,对HBVM阳性者宜选择对肝脏损害较轻的药物 ,同时给予适当的护肝治疗 ,并密切监测肝功能的变化。
Objective To explore the influence to hepatic function caused by liver virus infection of tuberculosis cases during chemical anti-tuberculosis treatment and relative countermeasure.Methods Retrospective analysis on the clinical data of 1?746 pulomary tuberculosis cases(PTB) There were evidences on liver function damaged of 160 cases .Results 68 cases(38.64%)out of 176 PTB suffered with HBVM positive Were obsenred fo be damaged on their liver function.While 70(4.7%)out of 1490 suffers with HBVM negative.And among 80 cases without HBVM test,there were 22 cases(27.5%)with liver function damaged evidences.There was a significant difference( P <0.01)of liver tunction damaged incidence between HBVM positive and negative PTB cases.Most of the liver function dannaged were observed from 15 to 90 days after receiving treatment.Conclusion The liver virus infection during short-term chemical treatment will influence hepatic function.Testing HBVM and hepatic function is necessary before providing anti-tuberculosis treatment for the PTB cases.It is important to select some drug with minor side effections on liver function for the PTB cases with HBVM positive result.In the meantime,proper liver protection treatment,and closely observation on change of hepatic function should be taken.
出处
《中国防痨杂志》
CAS
北大核心
2004年第1期50-52,共3页
Chinese Journal of Antituberculosis
