摘要
目的 :探讨N 乙酰基转移酶 (NAT2 )基因型与异烟肼、利福平治疗肺结核致肝毒性的相关性。方法 :通过聚合酶链反应 限制性片段长度多态性 (PCR RFLP)技术分析 6 7例经利福平、异烟肼治疗后发生或未发生肝功能异常的肺结核患者NAT2基因多态性的部位、性质及发生率。结果 :病例组和对照组 85 7位密码子多态性分别是 2 0 .3%和 7.1% ,两组差异显著。结论 :NAT2基因型与异烟肼和利福平所致肝毒性关系密切 ,其中 85 7位密码子点突变可能是结核患者发生肝毒性的易感基因型之一。
Objective:To investigate the relationship between the susceptibility of isoniazid and rifampicin-induced hepatotoxicity and the N-acetyltransferase 2(NAT2) genotype in the tuberculosis patients.Methods:NAT2 gene was analyzed in 67 pulmonary tuberculosis patients who had normal or abnormal hepatic function by PCR-RFLP.Results:The frequencies of NAT2 gene mutation at codon 857 in patient group and control group were 20.3% and7.1%,respectively,there were significant difference. Conclusion:NAT2 gene mutation at codon 857 might be one of susceptible genotype in the tuberculosis patients whose hepatic functions were abnormal.
出处
《军医进修学院学报》
CAS
2004年第3期239-240,共2页
Academic Journal of Pla Postgraduate Medical School
