摘要
目的探讨蛋白质营养不良对药物性肝损害的影响。方法对2001年9月至2003年5月住院治疗,合并蛋白质营养不良初治肺结核患者137例,采用标准规化抗结核药物治疗方案,观察药物性肝损害情况。并以同期住院治疗的不合并蛋白质营养不良的初治肺结核患者811例为对照。结果合并蛋白质营养不良初治肺结核患者,在治疗第l个月出现药物性肝损害较对照组高(χ2=4.614,P=0.032,RR=1.5);在治疗第l个月的药物性肝损害发生率,较治疗第2个月高(χ2=15.191,P=0.001)。女性和HBsAg(+)患者发生药物性肝损害率较高,但无显著性差异(P<0.05);年龄和肺结核病灶与抗结核药物所致肝损害发生无关(P<0.05)。结论在肺结核并蛋白质营养不良的患者治疗过程中,较容易出现药物性肝损害。因此在临床治疗上,应注意监测其肝功能变化以及注意改善其营养状态,减少药物性肝损害发生。
Objective To explore the influence of protein-malnutrition to the drug-induced hepatitis due to anti-tuberculosis drags.Methods 137 patients new pulmonary tuberculosis with protein-malnutrition hospitalized in our department from September 2001 to May 2003 was observed for the their drug-induced hepatitis, who was treated by the first line anti-tuberculosis drugs. And with the same period hosptitalization, 811 patients new pulmonary tuberculosis with non-protein-malnutrition were selected as the control group, Results The rate of the drug-induced hepatitis of new pulmonary tuberculosis with protein-malnutrition was higher, during the first month, than that of the control group（22.6% ,X^2 =4.614, P =0.032, RR = 1.5）. And the rate of that was higher than that of the same group, during the second month（X^2 = 15. 191, P = 0.001）.The drug-induced hepatitis rate of female with HBsAg（ ＋ ）occurrence was higher, but there was no significant statistical difference （P 〈 0.05）.There was no relation of age and the scope of tuberculosis focus with the drag-induced hepatitis （ P 〈 0.05）. Conclusion The protein-malnutrition tuberculosis patients in the treatment process emergence medicine liver function injures easily, so that we should monitor the clinical treatment for their liver function changes and pay attention to improve their nourishment appearance for reducing the medicine liver function injure.
出处
《中国防痨杂志》
CAS
2006年第2期83-86,共4页
Chinese Journal of Antituberculosis
基金
广东省广州市科委课题(2003Z1-E001)
关键词
抗结核药物
结核
肺
肝损害
蛋白质营养不良
Anti-tuberculosis drugs
Pulmonary tuberculosis
Drug - induced hepatitis
Protein-malnutrition
