摘要
目的:探讨抗结核药物诱导肝损伤的影响因素。方法:采用问卷调查和查阅病历的方法,调查516例初治结核病患者,内容包括人口学特征、个人疾病史、结核病治疗期间合并使用其他药物史、健康相关行为等,按照相关标准将在6个月观察期内发生肝损伤者定义为"病例组",未发生肝损伤者定义为"对照组",采用Logistic回归分析探讨这些因素对抗结核药物诱导肝损伤的影响。结果:多因素Logistic回归分析结果提示,与抗结核药物诱导肝损伤显著关联的因素是女性(OR=0.616;95%CI=0.398～0.954)、食鱼生行为(OR=2.072;95%CI=1.273～3.373)、肺外结核(OR=6.122;95%CI=1.684～22.262)、乙肝表面抗原阳性(OR=4.202;95%CI=2.349～7.517)和低蛋白血症(OR=2.012;95%CI=1.146～3.532)。结论:抗结核药物诱导肝损伤受多方面因素的影响。
Objective： To explore the influence factors of liver injury induced by anti-tuberculosis drugs. Method： 516 tuberculosis patients newly diagnosed were investigated with a structure questionnaire and reading case history about their demographics, individual disease history, history of other drugs used in the period of anti-tuberculosis treatments, health-related behaviors, etc. Logistic regression analyses were conducted to explore the impact of these factors on liver injury caused by anti-tuberculosis treatments. Result： The results of multivariate logistic regression analyses indicated that the following factors were significantly associated with liver injury caused by anti-tuberculosis drugs. The patients associated with the liver injury were female （ OR = 0. 616 ; 95% CI = 0. 398 - 0. 954 ）, eating undercooked freshwater fishes （ OR = 2. 072 ; 95% CI = 1. 273 - 3. 373 ）, extra-pulmonary tuberculosis （ OR = 6. 122 ;95% C = 1. 684 - 22. 262 ）, positive serum hepatitis B virus surface antigen （ OR = 4. 202 ; 95% CI = 2. 349 - 7. 517 ） and hypo-albuminemia （ OR = 2. 012 ; 95% CI = 1. 146 - 3. 532）. Conclusion： The anti-tuberculosis drug-induced liver injury is affected by multiple factors.
出处
《药物流行病学杂志》
CAS
2008年第6期377-380,共4页
Chinese Journal of Pharmacoepidemiology
关键词
抗结核药物
诱导
肝损伤
影响因素
Anti-tuberculosis drug
Induce
Liver injury
Influence factor
