摘要
[目的]探讨短程化疗方案对乙型肝炎标志物(HBVM)阳性初治涂阳肺结核患者肝功能的影响。[方法]采用病例对照研究的方法,随机选取乙型肝炎病毒标志物阳性且肝功能正常的初治涂阳肺结核患者75例,选择乙型肝炎病毒标志物检测阴性的初治涂阳肺结核患者55例作为对照组,对HBVM和肝功能进行检测。[结果]75例乙肝病毒标志物阳性患者发生药物性肝炎20例(26.67%),55例乙肝病毒标志物阴性患者发生药物性肝炎2例(3.63%),乙肝标志物阳性患者与乙肝标志物阴性患者药物性肝炎发生率差异有显著性(P< 0.01)。[结论]2HRZE/4HR短程化疗方案对HBVM阳性和阴性初治肺结核患者的肝功能影响明显不同。在对这两类患者进行抗结核化疗时,应特别关注抗结核药物对HBVM阳性患者的影响。
[Objective] To explore the effect of short term chemotherapy on the liver function of tuberculous patient with positive hepatitis B virus marker （HBVM）. [Methods] A total of 75 smear positive tuberculous patients with positive HBVM and normal liver function were selected as the tested group and 55 cases of smear positive but with negative HBVM tuberculous patients as control. All the patients were initially treated with short term chemotherapy （2HRZE/4 HR） for tuberculosis. HBVM were detected with EIA method and SGPT, AST, ALT, T2Bil and D2Bil were determined forliver function every month. [Results] The incidence of drug hepatitis was 26.67% （20/75） in HBVM positive group, but that for HBVM negative group was only 3.63 % （2/55）. The difference among them was significant statistically （ P 〈 0.01 ）. [Conclusion] The effect of short term chemotherapy on the liver function in positive HBVM tuberculous patient is very obvious, therefore in dealing with anti-tuberculous chemotherapy, special attention should be paid on the HBVM positive tuberculous patient.
出处
《武警医学院学报》
CAS
2006年第6期571-573,共3页
Acta Academiae Medicinae CPAPF
