摘要
目的观察并探讨血浆置换(PE)治疗后重型肝炎患者血清中HBV-DNA载量的变化及其临床意义。方法随机选取48例乙型肝炎病毒标志物阳性的重肝患者,在内科基础治疗上加用血浆置换治疗。观察患者在PE治疗前后血清中HBV-DNA载量的变化及各项肝功能指标的变化。结果48例患者经PE治疗,血清HBV(?)DNA载量明显下降,治疗有效组比治疗无效组降低更明显,对肝功能和临床症状的改善也更明显。结论PE治疗可有效去除重型肝炎患者血清中HBV-DNA,从而减轻由其诱发的机体免疫反应,改善临床症状及肝功能,提高患者的存活率。
Objective To observe and evaluate the effect of plasma exchange（PE） on the serum level of HBV - DNA and its clinical significance in patients with severe hepatitis . Methods PE treatment on the basis of medical treatment was performed in 48 patients with severe hepatitis B, who were randomly selected from the patients with severe hepatitis B treated in our department from October 2000 to October 2003, The serum level of HBV - DNA and liver fimetion before and after PE therapy were examined. Restults The serum level of HBV - DNA was significantly decreased and the liver function were significanfly improved after PE therapy corollated to the pretreatment （ P 〈 0.01 ） in all the patients. The decrease in the level of serum HBV - DNA and the improvement in the liver function in the recovering patients were more significant than those in the unchanged patients （ P 〈 0.01 ）. Conclusions The PE therapy can effectively purge the serum of HBV - DNA in patients with severe hepatitis B, reduce the iminunoreaetions, and improve the liver function. The survival rat of the patients should be increased.
出处
《华南国防医学杂志》
CAS
2005年第4期1-3,共3页
Military Medical Journal of South China
