摘要
目的 探讨VEGF和c myc在胆管癌组织中的表达和二者之间的相关性及其在胆管癌发生、发展和转移中的作用。方法 应用免疫组化ABC法对 38例胆管癌组织和 2 0例正常胆管组织中VEGF和c myc的表达进行检测。结果 VEGF和c myc在胆管癌组织中的表达阳性率分别为 84 .2 % (32 /38)和 6 5 .8% (2 5 /38) ,明显高于正常胆管组织中的表达阳性率〔5 0 .0 % (10 /2 0 )和 2 0 .0 % (4/2 0 )〕 ,差异有统计学意义 (P<0 .0 5 ) ;VEGF与c myc的表达呈正相关 (r=0 .99,P<0 .0 1) ,二者的协同表达与胆管癌的淋巴结转移有关 ,而与肿瘤的分级无关。结论 VEGF可能在胆管癌形成、发展和转移中与c myc基因有协同作用 ,且与胆管癌的淋巴结转移有关。
Objective To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and c-myc with the occurrence, development and metastasis of cholangiocarcinoma.Methods The expression of VEGF and c-myc in 38 of cholangiocarcinoma tissue and in 20 of normal bile duct tissue were examined by immunochemistry.Results The positive rates of VEGF and c-myc in cholangiocarcinoma tissue were 84.2% and 65.8% respectively, and 50.0% and 20.0% respectively in normal bile duct tissue. The positive rates of VEGF and c-myc in cholangiocarcinoma were significantly higher than that in normal bile duct tissue (P<0.05). The correlation between expressions of c-myc and VEGF was very significant (r=0.99, P<0.01). The expression of VEGF and c-myc in cholangiocarcinoma was related with metastasis of cholangiocarcinoma.Conclusion VEGF and c-myc play important roles in occurrence, development and metastasis of cholangiocarcinoma
出处
《中国普外基础与临床杂志》
CAS
2004年第2期139-141,共3页
Chinese Journal of Bases and Clinics In General Surgery
