摘要
目的 探讨P2 1蛋白表达与上皮性卵巢癌预后的关系。方法 30例正常卵巢、30例良性卵巢肿瘤、10 8例上皮性卵巢癌标本用免疫组化的方法检测P2 1蛋白表达。结果 正常卵巢组、良性肿瘤组、卵巢癌组的P2 1蛋白阳性表达率分别为 88 33%、80 0 0 %、6 4 81% ,恶性组阳性率低于其它两组 (P =0 .0 14 )。P2 1( - )和P2 1( + )患者的 5年生存率分别为 31 5 8%和 4 7 14 % ,差异有显著性 (P =0 0 2 4 6 )。结论 P2
Objective To identify the significance of p21 expression in patients with epithelial carcinoma.Methods Thirty normal ovary,30 benign epithelial ovarian tumor and 108 epithelial carcinoma formalin-fixed specimens were retrospectively reviewed.p21 protein expression was detected by immunohistochemical staining.Results The positive rates of p21 were 88.33% in normal ovarian group,80.00% in benign ovarian tumor group,and 64.81% in ovarian carcinoma group.The positive rate of p21 of epithelial ovarian carcinoma group was lower than other two groups ( P =0.0147).The p21 staining was associated with the 5-year survival ( P =0.0246).Conclusion The p21 expression has some significance in predicting the prognosis of epithelial ovarian carcinoma.
出处
《现代肿瘤医学》
CAS
2004年第1期6-7,共2页
Journal of Modern Oncology
