摘要
目的探讨p21ras、p73在子宫内膜腺癌中的表达及意义。方法用免疫组化SP法在15例正常增生期子宫内膜、19例子宫内膜非典型增生及61例子宫内膜腺癌组织中检测p21ras、p73的表达情况。结果随着子宫内膜病变的恶性进展,p21ras和p73的阳性表达率上调,且两者在子宫内膜腺癌中表达的相关性呈正相关(P<0.01)。p21ras和p73表达与子宫内膜腺癌病理学分级有关(P<0.05),与子宫内膜腺癌的临床分期、肌层浸润、淋巴结转移无关。结论 p21ras、p73与子宫内膜腺癌的发生和发展有关,且两者存在协同作用。联合检测p21ras、p73的表达可能成为子宫内膜腺癌高危人群早期筛查、病理诊断的参考指标。
Objective To investigate the expression of p21ras and p73 in endometrioid adenocarcinoma and its clinical significance. Methods Immunohistochemistry was applied to detect the expression of p21ras and p73 protein in 15 cases of normal proliferating endometrial tissues,19 cases of atypical hyperplasia and 61 cases of endometrioid adenocarcinoma. Results The positive rates of p21ras and p73 gradually increased from normal proliferating endometrial tissues to endometrioid adenocarcinoma.There was a positive correlation between p73 and p21ras in endometrioid adenocarcinoma（P0.01）.Expression of p21ras and p73 was associated with the histological grade（P0.05）,but not related with clinical stage,myometrial invasion and lymph node metastasis. Conclusion The results suggest that the activation of p21ras and p73 may be correlated with the genesis and development of endometrioid adenocarcinoma.The combined detection of p21ras and p73 may provide a reference for early screening of high-risk subjects,pathological diagnosis of endometrioid adenocarcinoma.
出处
《山西医科大学学报》
CAS
2011年第10期818-821,859,共5页
Journal of Shanxi Medical University
