摘要
目的探讨claudin-4和PTEN在子宫内膜癌中的表达、意义及两者之间的关系。方法采用免疫组化SP法检测75例子宫内膜癌、35例不典型增生和28例增生期子宫内膜的claudin-4和PTEN表达。结果从正常增生期子宫内膜、非典型增生、到宫内膜癌,claudin-4阳性表达呈逐渐增高趋势,组间差异有统计学意义(P<0.05);PTEN阳性表达呈下降趋势,组间差异有统计学意义(P<0.05)。claudin-4高表达与癌组织肌层浸润有关(P<0.05),与组织分级、手术病理分期、组织学类型及有无淋巴结转移无关;PTEN低表达与肌层浸润有关(P<0.05),与组织分级、手术病理分期、组织学类型、及有无淋巴结转移无关。claudin-4与PTEN呈负相关(r=-0.36,P<0.05)。结论claudin-4高表达可能促进了子宫内膜癌发生和发展,PTEN低表达在这一过程中可能具有协同作用。
Objective To investigate the expression and significance of claudin-4 and PTEN in endomentriold adenocarcinoma. Methods Immunohistochemistry was applied to detect the expression of claudin-4 and PTEN in 75 cases of endomentrioid adenocarcinornas,35 dysplasias and 28 proliferating endometria. Results From proliferative endometrium,endometrial dysplasia to endometrial the positive expression of claudin-4 increased gradually. There was a significant difference between groups （P〈0. 05）. The positive expression of PTEN in three groups showed an increasing trend. The difference was significant （P〈 0. 05）. The overexpression of claudin-4 was correlated to myometrialinvasion（P（0. 05）, but not to histological grade invasion（P〉0. 05）, histological grade pathologic stage lymph node metastasis nor histological type;the hypoexpression of PTEN was correlated to myometrialinvasion（P（0. 05）, not to those of the others. Negative correlation was found between claudin-4 and PTEN（r = -0. 36, P（0. 05） . Conclusion Overexpression of claudin-4 may be involved in carcinogenesis and development of endometrioid adenocarcinoma, and hypoexpression of PTEN may contribute to these process.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2009年第7期583-586,共4页
Cancer Research on Prevention and Treatment
基金
安徽省教育厅自然科学基金资助项目(2003KJ0042C)
