摘要
目的:探讨加巴喷丁治疗2型糖尿病周围神经痛的临床疗效。方法:选择2014年10月-2016年10月我院收治的74例2型糖尿病伴周围神经痛患者为研究对象,按随机数字表法分为对照组和观察组,各37例。对照组采用常规治疗,观察组在常规治疗基础上给予加巴喷丁治疗,第1 d口服100 mg,tid;第2 d口服200 mg,tid;第3 d口服300 mg,tid;此后以300 mg,tid的用药量维持治疗4周。比较两组神经痛等级评分以及血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6的指标水平。结果 :观察组治疗后血清TNF-α、IL-6水平显著低于对照组(P<0.05);观察组治疗后1周,2周,4周疼痛视觉模拟评分均显著低于对照组(P<0.05)。观察组治疗总有效率为97.3%,显著高于对照组的78.38%,差异有统计学意义(P<0.05)。观察组不良反应发生率为2.7%,显著低于对照组的27.03%,差异有统计学意义(P<0.05)。结论 :加巴喷丁治疗糖尿病周围神经痛临床疗效显著,不良反应小,值得临床推广。
Objective:To investigate the clinical efficacy of gabapentin in the treatment of type 2 diabetic peripheral neuropathic pain. Methods:74 cases of patients with type 2 diabetic peripheral neuropathic pain admitted to our hospital from October 2014 to October 2016 were selected as subjects and divided into control group and observation group according to random number table, 37 cases in each group. The patients in the control group were given conventional treatment. The patients in the observation group were treated with gabapentin on the basis of conventional treatment, orally taking 100 mg on the first day, tid; orally taking 200 mg on the second day, tid; orally taking 300 mg on the third day, tid; thereafter, 300 mg, tid, and the treatment was maintained for 4 weeks. The score of neuropathic pain grade and serum tumor necrosis factor(TNF)-α, IL-6 indicators level were compared between the two groups. Results:The serum TNF-α and IL-6 levels in the observation group were significantly lower than those in the control group(P<0.05). The visual analog pain score after 1 week, 2 weeks and 4 weeks of treatment in the observation group were significantly lower than those in the control group(P<0.05). The total effective rate of the observation group was 97.3%, which was significantly higher than that(78.38%) of the control group(P<0.05). The incidence of adverse reactions in the observation group was 2.7%, which was significantly lower than that(27.03%) in the control group(P<0.05). Conclusion:Gabapentin has significant clinical efficacy in the treatment of diabetic peripheral neuropathic pain and less adverse reactions, and is worthy of clinical promotion.
出处
《中国执业药师》
CAS
2018年第5期72-74,共3页
China Licensed Pharmacist
关键词
加巴喷丁
糖尿病
周围神经痛
临床疗效
Gabapentin
Diabetes
Peripheral Neuropathic Pain
Clinical Efficacy
