摘要
目的探讨普瑞巴林联合硫辛酸对糖尿病痛性神经病变患者的影响。方法选取重庆市第七人民医院2019年7月至2020年12月收治的86例糖尿病痛性神经病变患者,按照随机数字表法将其分为参照组(43例)、试验组(43例)。两组均接受常规治疗,参照组在此基础上采取硫辛酸联合加巴喷丁治疗,试验组则采用硫辛酸联合普瑞巴林治疗,疗程均为4周。比较两组疗效及治疗前后的数字评分法(NRS)评分、密歇根糖尿病神经病变评分(MDNS)及神经传导速度。记录两组药物不良反应(ADR)发生情况。结果治疗后,试验组疗效优于参照组,差异有统计学意义(P<0.05)。治疗后,两组NRS评分及MDNS均低于治疗前,且试验组低于参照组,差异有统计学意义(P<0.05)。治疗后,两组正中神经、腓总神经运动神经传导速度、感觉神经传导速度均高于治疗前,差异有统计学意义(P<0.05)。两组ADR总发生率比较,差异无统计学意义(P>0.05)。结论对糖尿病痛性神经病变患者实施普瑞巴林联合硫辛酸治疗,其效果优于硫辛酸联合加巴喷丁治疗,且ADR发生率较低。
Objective To investigate the effect of Pregabalin combined with Lipoic acid on patients with diabetic painful neuropathy.Methods A total of 86 patients with diabetic painful neuropathy admitted to the Seventh People’s Hospital of Chongqing from July 2019 to December 2020 were selected and divided into control group(43 cases)and experimental group(43 cases)according to random number table method.Both groups received conventional treatment,the control group was treated with Lipoic acid combined with Gabapentin,and the experimental group was treated with Lipoic acid combined with Pregabalin,the course of treatment was four weeks.The efficacy,numerical rating scale(NRS)score,Michigan diabetic neuropathy score(MDNS),and nerve conduction velocity before and after treatment were compared between the two groups.The occurrence of adverse drug reaction(ADR)was recorded in the two groups.Results After treatment,the therapeutic effect of experimental group was better than that of control group,and the difference was statistically significant(P<0.05).After treatment,NRS scores and MDNS in two groups were lower than those before treatment,and experimental groups were lower than those of control group,and the differences were statistically significant(P<0.05).After treatment,the motor nerve conduction velocity and sensory nerve conduction velocity of median nerve and common peroneal nerve in two groups were higher than before treatment,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of ADR between the two groups(P>0.05).Conclusion The treatment effect of Pregabalin combined with Lipoic acid is better than that of Lipoic acid combined with Gabapentine in patients with diabetic painful neuropathy,and the incidence of ADR is lower.
作者
付晓娟
李训军
余剑
杨宗发
姜玉琴
FU Xiaojuan;LI Xunjun;YU Jian;YANG Zongfa;JIANG Yuqin(Pharmaceutical Engineering Center,Chongqing Medical and Pharmaceutical College,Chongqing401331,China;the Seventh People’s Hospital of Chongqing,Chongqing400054,China;Zein Biotechnology Co.,LTD,Chongqing401220,China)
出处
《中国医药导报》
CAS
2023年第9期71-74,79,共5页
China Medical Herald
基金
教育部职业教育改革创新课题项目(HBKC214062)
重庆市高等教育教学改革研究项目(201065S)
重庆医药高等专科学校教育教学改革研究项目(CQYGZJG1902)。
