摘要
目的 :探究采用比索洛尔联合福辛普利对冠心病患者心源性猝死(SCD)的影响。方法 :选取我院2015年7月-2016年7月收治的140例冠心病患者为研究对象,按随机数字表法分为对照组与联合组,各70例。所有患者均给予洋地黄、利尿剂、硝酸盐类进行常规治疗,对照组给予口服福辛普利(10 mg,qd),联合组给予口服比索洛尔(2.5 mg,qd)+福辛普利(同对照组)联合治疗。两组均治疗6个月,观察两组SCD发生率、死亡率、不良反应、总有效率、心功能指标变化情况。结果 :联合组总有效率明显高于对照组,差异有统计学意义(P<0.05);联合组SCD发生率、死亡率、不良反应发生率均低于对照组(P<0.05),联合组左心室收缩末径(LVESD)、左心室舒张末径(LVEDD)水平明显低于对照组,左心室射血分数(LVEF)水平高于对照组,差异有统计学意义(P<0.05)。结论 :采用比索洛尔联合福辛普利治疗冠心病可以降低SCD发生率,改善心功能,疗效安全可靠。
Objective:To explore the effect of bisoprolol combined with fosinopril in the treatment of sudden cardiac death(SCD) in patients with coronary heart disease. Methods:140 patients of coronary heart disease treated in our hospital from July 2015 to July 2016 were selected as subjects and divided into control group and combined group according to the random number table method, 70 cases in each group. All patients were given conventional treatment of digitalis, diuretics and nitrates. The patients in the control group were given oral fosinopril(10 mg, qd), and the patients in the combined group were given combined treatment of oral bisoprolol(2.5 mg, qd) +fosinopril(10 mg, qd). The patients in the two groups were treated for 6 months, and the incidence of SCD, mortality, adverse reactions, total effective rate and changes in cardiac function indexes were observed. Results:The total effective rate of the combined group was significantly higher than that of the control group(P<0.05); the incidences of SCD, mortality, and adverse reactions were lower in the combined group than those in the control group(P<0.05); the left ventricular end-systolic diameter(LVESD) and left ventricular end-diastolic dimension(LVEDD) levels were significantly lower in the combined group than those in the control group; the left ventricular ejection fraction(LVEF) level was higher in the combined group than that in the control group(P<0.05). Conclusion:Bisoprolol combined with fosinopril in the treatment of coronary heart disease can reduce the incidence of SCD and improve heart function, and is safe and reliable.
出处
《中国执业药师》
CAS
2018年第5期28-30,41,共4页
China Licensed Pharmacist
关键词
心源性猝死
冠心病
比索洛尔
福辛普利
Sudden Cardiac Death
Coronary Heart Disease
Bisoprolol
Fosinopril
