摘要
目的观察加味茵陈蒿汤灌肠辅助治疗新生儿高胆红素血症的临床疗效。方法选取2017年11月至2018年9月江苏省中医药研究院儿科新生儿监护室住院的新生儿高胆红素血症患儿66例,按随机数字表法分为治疗组和对照组,各33例。2组均给予蓝光照射常规西医疗法,对照组给予双歧杆菌乳杆菌嗜热链球菌三联活菌片口服,治疗组在对照组治疗方法的基础上给予中药汤剂灌肠治疗。治疗7 d后,比较2组的临床疗效以及治疗前后血清总胆红素(TBIL)、间接胆红素(IBIL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、肌酐(Cr)和尿素(BUN)水平变化情况以及2组的不良反应。结果治疗组的痊愈率为84.8%,显著高于对照组的57.6%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组的TBIL、IBIL、ALT、AST、Cr和BUN水平比较,差异均无统计学意义(P>0.05),具有可比性;治疗后,2组的TBIL、IBIL和BUN水平均较同组治疗前显著下降(P<0.05),且治疗组下降更显著,差异有统计学意义(P<0.05)。ALT、AST和Cr水平与同组治疗前比较,差异均无统计学意义(P>0.05)。2组治疗过程中,均未出现呕吐、腹胀等不良反应。结论加味茵陈蒿汤灌肠辅助治疗新生儿高胆红素血症疗效确切,药物通过肠道黏膜吸收,进入体内达到清热解毒、利湿退黄的作用,避免了口服药物对脾胃的刺激和肝脏的损伤,值得临床推广应用。
Objective To observe the clinical efficacy of Jiawei Yinchenhao Tang(加味茵陈蒿汤)enema in adjuvant treatment of hyperbilirubinemia of newborn.Methods Sixty-six cases of hyperbilirubinemia of newborn hospitalized in neonatal care unit of department of pediatrics in Jiangsu Academy of Traditional Chinese Medicine were chosen and divided into treatment group and control group according to random number table method,with 33 cases in each.The 2 groups were both given the routine Western treatment including blue light irradiation,the control group was given oral administration of bifidobacterium triplex viable bacteria,while the treatment group was given enema of Chinese medicinal decoction on the basis of the control group.After treatment for 7 days,the clinical efficacy of the 2 groups,changes of total bilirubin(TBIL),indirect bilirubin(IBIL),glutamic-pyruvic transaminase(ALT),glutamic oxalacetic transaminase(AST),creatinine(Cr)and carbonyldiamide(BUN)before and after treatment in the two groups,and adverse reactions in 2 groups were compared.Results The recovery rate of the treatment group was 84.8%,which was significantly higher than 57.6%of the control group,and the difference was statistically significant between the two groups(P<0.05).Before treatment,there was no statistically significant difference in TBIL,IBIL,ALT,AST,Cr and BUN between the two groups(P>0.05),and they were comparable.After treatment,the levels of TBIL,IBIL and BUN of the two groups all significantly decreased compared with the same group before treatment,moreover,the treatment group decreased more significantly,and the difference was statistically significant(P<0.05).After treatment,there was no statistically significant difference in the levels of ALT,AST and Cr compared with the same group before treatment(P>0.05).No adverse reactions such as vomiting and abdominal distension occurred in the two groups during the treatment.Conclusion It has definite curative effects to use Jiawei Yinchenhao Tang enema in adjuvant treatment of hyperbi
作者
张程
阮为勇
ZHANG Cheng;RUAN Weiyong(Department of Pediatrics,Jiangsu Academy of Traditional Chinese Medicine,Nanjing,Jiangsu,210028,China)
出处
《中医儿科杂志》
2019年第5期35-38,共4页
Journal of Pediatrics of Traditional Chinese Medicine
关键词
高胆红素血症
新生儿
灌肠
加味茵陈蒿汤
中西医结合
临床观察
hyperbilirubinemia
newborn
enema
Jiawei Yinchenhao Tang(加味茵陈蒿汤)
combined traditional Chinese and Western medicine
clinical observation
