摘要
目的研究乳癖散结胶囊联合他莫昔芬治疗乳腺增生患者的治疗效果。方法随机抽取80例乳腺增生患者作为研究对象,采用随机综合平衡法分为他莫昔芬组和联合组,各40例。他莫昔芬组采用他莫昔芬治疗,联合组采用他莫昔芬联合乳癖散结胶囊治疗。观察治疗效果,包括显愈率及治疗过程中不良反应发生率,使用疼痛评分对患者治疗前后疼痛感进行测定,后采用统计学软件SPSS 21.0对比分析组间数据。结果 (1)联合组痊愈34例、显效4例、无效2例,显愈率95.00%(38/40);他莫昔芬组痊愈24例、显效5例、无效11例,显愈率72.50%(29/40),两组比较,差异有统计学意义(χ~2=5.878,P=0.015)。(2)联合组恶心呕吐1例、月经失调0例、头痛眩晕0例,不良反应发生率2.50%(1/40);他莫昔芬组恶心呕吐4例、月经失调3例、头痛眩晕3例,不良反应发生率25.00%(10/40),两组比较,差异有统计学意义(χ~2=6.746,P=0.009)。(3)联合组治疗后疼痛评分[(2.01±0.23)分比(5.68±1.23)分,P <0.001]显著低于治疗前;他莫昔芬组治疗后疼痛评分[(3.36±0.26)分比(5.65±1.28)分,P <0.001]显著低于治疗前,差异均有统计学意义。而且联合组治疗后疼痛评分[(2.01±0.23)分比(3.36±0.26)分,P <0.001]显著低于他莫昔芬组,差异有统计学意义。结论乳癖散结胶囊联合他莫昔芬治疗乳腺增生患者具有显著效果,能够准确减少不良反应及疼痛感对疗效造成的影响,值得应用于临床推广。
Objective To study the therapeutic effect of RupiSanjie Capsule combined with Tamoxifen in the treatment of patients with hyperplasia of mammary glands.Methods Eighty patients with hyperplasia of mammary glands were randomly selected as the study subjects.They were divided into tamoxifen group and combined group by random comprehensive balance method,40 cases each.The tamoxifen group was treated with tamoxifen,and the combined group was treated with tamoxifen combined with chylorrhea capsules.The therapeutic effects were observed,including the rate of development and the incidence of adverse reactions during the treatment.The pain scores were measured before and after treatment using the pain score,and the data between the groups were analyzed by statistical software SPSS 21.0.Results(1)The rate of cure in the combined group(95.00%)and the rate of tamoxifen(72.50%)were statistically significant(P <0.05).(2)The incidence of adverse reactions in the combined group(2.50%)and the incidence of adverse reactions in the tamoxifen group(25.00%)were statistically significant(P <0.05).(3)The pain score of the combined group was lower than that of the tamoxifen group and before treatment,which was statistically significant(P <0.05).Conclusion RupiSanjie Capsule combined with tamoxifen in the treatment of breast hyperplasia patients has significant effect,can accurately reduce the impact of adverse reactions and pain on the efficacy,it is worthy of clinical application.
作者
裴蓓
朱玉兰
成琳
PEI Bei;ZHU Yu-lan;CHEN Lin(Breast surgery,Changzhou No.2 People's Hospital Affiliated to Nanjing Medical University,Nanjing213003,China)
出处
《中国误诊学杂志》
CAS
2018年第9期402-404,共3页
Chinese Journal of Misdiagnostics
基金
国家自然科学基金资助项目(81502294)
常州市科技计划项目(CJ20159044)
关键词
乳癖散结胶囊
他莫昔芬
乳腺增生
不良反应
疼痛
chylorrhea capsules
tamoxifen
breast hyperplasia
adverse reactions
pain
