摘要
雄黄,辛温,有毒,归肝、大肠经,属于以毒攻毒的药物,具有解疟抗癌、解毒杀虫、燥湿祛痰的作用。古代医家常应用雄黄治疗痈肿疔疮,聚积腹痛等,近现代医家用以治疗恶性肿瘤及血液病,由古到今为临床所用。雄黄的毒性导致其用药安全范围小,现代学者将传统中药与纳米科技手段相结合,将雄黄研磨成为纳米雄黄,相比较雄黄可言,提高了生物利用度,降低了雄黄的体内毒性,将雄黄的临床应用推动到了新的高度。现代药理研究通过运用纳米雄黄干预肺癌细胞、卵巢癌细胞、皮肤癌细胞、宫颈癌细胞和白血病细胞等实验,证实纳米雄黄具有抑制细胞增殖,诱导细胞凋亡、诱导细胞分化、抑制核酸合成、抑制新生血管生成等功能,还具有抗病毒、杀菌镇痛的功效。现代毒理研究通过应用不同浓度的纳米雄黄制剂给予小鼠灌胃治疗,记录各时间段小鼠的症状体征及各项辅助检查指标,得出安全剂量下纳米雄黄对血液生化指标等影响均处于正常范围内。临床试验应用纳米雄黄外敷治疗恶性肿瘤破溃创面,发现纳米雄黄有促进患者肿瘤破溃创面愈合,减轻疼痛,缓解渗血、流脓、散发恶臭味等临床症状,提高患者生活质量的作用。并且用药简易,患者依从性好,无需住院治疗,节约医疗资源,值得临床推广应用。
Realgar is toxic and belongs to drug of poison attack,with anti-cancer,anti-pest,dry wet and expectorant effects. Ancient doctors often used realgar to treat carbuncle,boil,abdominal pain and other diseases.Modern doctors use it to treat malignant tumors and blood diseases. The toxicity of realgar results in a small range of safety in its drug use. Modern scholars combine traditional Chinese medicine with nano-technology means to grind realgar into nano-realgar. Compared with realgar,nano-realgar has an improved bioavailability and reduced toxicity in vivo. Modern pharmacological researches use nano-realgar to interven lung cancer cells,skin cancer cells,cervical cancer cells,ovarian cancer cells and leukemia cells in experiments,which confirmed that nano-realgar has effects in inhibiting cell proliferation,inducing apoptosis and cell differentiation,inhibiting nucleic acid synthesis and angiogenesis,but with antiviral,sterilization of analgesic effects. Modern toxicological studies have been conducted in mice through intragastric treatment with different concentrations of nano-realgar preparation. The symptoms and signs of mice and various auxiliary examination indexes were recorded at different time periods. It was concluded that nano-realgar has regular effects on blood biochemical indexes at safe doses. In clinical trials,nano-realgar was applied to treat damaged wound surface of malignant tumor. It was found that nano-realgar can promote healing of wound surface of tumor,alleviate pain,relieve clinical symptoms,such as bleeding,purulence and odor,and improve quality of life of patients. In addition,with a simple usage and good patient compliance,administration with nano-realgar requires no hospitalization,can save medical resources,and is worthy of clinical promotion and application.
作者
裴可
冯慧超
郑文利
李慧杰
PEI Ke;FENG Hui-chao;ZHENG Wen-li;LI Hui-jie(Shandong University of Traditional Chinese Medicine(TCM),Ji'nan 250355,China;Affiliated Hospital of Shandong University of TCM,Ji'nan 250011,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2019年第5期214-219,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81503542)
国家科技支撑计划项目(2015BA104B00)
关键词
雄黄
纳米雄黄
药理研究
毒理研究
临床应用
realgar
nano-realgar
pharmacological researches
toxicological studies
clinical application
