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老年慢性支气管炎患者血清ANCA水平及其与降钙素原、超敏C反应蛋白联合检测的价值 被引量:12

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摘要 目的探讨老年慢性支气管炎患者血清抗中性粒细胞胞质抗体(ANCA)水平及其与降钙素原(PCT)、超敏C反应蛋白(hs-CRP)联合检测的价值。方法选择老年慢性支气管炎急性发作期(AECB)患者120例作为AECB组,同期老年健康体检者120例作为对照组(NC组)。检测两组受试者血清ANCA、PCT、hs-CRP水平。结果 AECB组血清ANCA、PCT、hs-CRP水平明显高于NC组,差异有统计学意义(P<0.05),重度AECB患者血清ANCA、PCT、hs-CRP水平明显高于轻度患者,差异有统计学意义(P<0.05),AECB患者治疗后血清ANCA、PCT、hs-CRP水平明显低于治疗前,差异有统计学意义(P<0.05),AECB患者血清ANCA水平与PCT、hs-CRP均呈正相关(r=0.524,P=0.000;r=0.537,P=0.000),血清ANCA、PCT、hs-CRP及三者联合诊断AECB的受试者工作特征(ROC)曲线下面积分别为:0.707、0.721、0.773、0.877,95%CI分别为0.704~0.710、0.719~0.724、0.770~0.775、0.875~0.880。结论老年慢性支气管炎患者血清ANCA水平升高,在AECB的诊断、病情严重程度评估、疗效评价中具有重要价值;ANCA与血清PCT、hs-CRP关系密切,三者联合检测可提高AECB的诊断价值。
作者 杨莉
出处 《中国老年学杂志》 CAS 北大核心 2019年第8期1868-1871,共4页 Chinese Journal of Gerontology
基金 浙江省自然科学基金一般项目(LY15H010005)
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