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中国成年人血清FGF21水平与冠心病风险 被引量：5

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摘要 目的探讨成纤维细胞生长因子21(FGF21)血清浓度与冠心病及代谢特征之间的关系。方法随机选取480例患者,均进行冠脉造影检查,其中确诊为冠心病者262例,非冠心病者218例。测定受试者血清FGF21浓度、血糖、血脂、血压、胰岛素等一些指标。动脉硬化的程度以病变血管的数目进行评估。结果血清FGF21浓度冠心病组明显高于非冠心病组,并随着病变血管数目的增加,其浓度明显升高。调整年龄、性别、体重指数后,相关性分析显示血清FGF21与血清总胆固醇及甘油三酯呈正相关。结论血清FGF21水平与冠心病风险呈正相关,其水平升高可作为冠心病独立预测因素。
作者 郭功亮 吴金义 张蕾 常宏 宫立程 徐海明 孙立群
机构地区 吉林大学第三医院心内科 吉林大学第一医院儿科门急诊
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第5期1233-1235,共3页 Chinese Journal of Gerontology
关键词 成纤维细胞生长因子21 冠心病 糖代谢 血脂代谢 胰岛素抵抗
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献13

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共引文献1

同被引文献39

  • 1杨丽霞,杨玉霞,齐峰,郭传明,王先梅,石燕昆,王燕,王红,郭瑞威.核转录因子PPARγ在冠心病患者冠状动脉损害中的作用[J].解放军医学杂志,2006,31(9):860-862. 被引量：1
  • 2胡大一.重视东方循证医学的证据,做好中国心血管疾病的预防[J].中国心血管病研究,2007,5(10):721-723. 被引量：42
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  • 9Wong CX, Abed HS, Molaee P, et al. ated with atrial fibrillation severity and Coil Cardiol, 2011,57 : 1745-1751. 被引量：1
  • 10Pericardial fat is associ- ablation outcome. J Am Venteclef N, Guglielmi , Balse E, et al. Human epicardial adi- pose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines. Eur Heart J, 2015,36:795-805a. 被引量：1

引证文献5

二级引证文献17

中国老年学杂志
2015年 第5期

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