摘要
目的探究成纤维细胞生长因子21(FGF21)和脂联素(APN)应用于急性冠状动脉综合征(ACS)近期预后的预测效能。方法对2017年7月—2018年8月收治的124例ACS患者的临床资料进行回顾性分析,随访6个月内发生不良心血管事件(MACE)者21例纳入不良组,未发生MACE者103例纳入良好组。比较2组入院时血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、FGF21、APN水平差异,绘制受试者工作特征(ROC)曲线,评价各指标分别预测及FGF21联合APN预测ACS患者近期预后的效能。结果不良组血清TG、LDL-C、FGF21水平均明显高于良好组,而血清APN水平则明显低于良好组(P<0.05,P<0.01)。TG、LDL-C预测ACS患者近期预后ROC曲线的曲线下面积均明显小于FGF21、APN及FGF21联合APN预测方案,FGF21、APN明显小于FGF21联合APN预测方案(P<0.05)。TG、LDL-C、FGF21、APN对应cut-off值分别为1.94 mmol/L、3.10 mmol/L、2.39 ng/L、6.96 mg/L。结论血清FGF21和APN水平能对ACS患者近期预后做出有效预测,临床早期检查能为尽早采取相应干预措施提供直观且准确的证据支持,有利于改善患者预后。
Objective To explore the predictive efficacy of fibroblast growth factor 21(FGF21)and adiponectin(APN)in the short-term prognosis of acute coronary syndrome(ACS).Methods The clinical data of 124 patients with ACS admitted from July 2017 to August 2018 were retrospectively analyzed.Patients with major adverse cardiovascular events(MACE)within 6 months of follow-up were included as poor group(n=21),and those without MACE were included as good group(n=103).The differences of levels of serum triglyceride(TG),low density lipoprotein cholesterol(LDL-C),FGF21 and APN were compared between the two groups at admission.The receiver operating characteristic(ROC)curve was drawn to evaluate the efficacy of each index in prediction and FGF21 combined with APN in prediction of the efficacy of short-term prognosis of ACS patients.Results The levels of serum TG,LDL-C and FGF21 in poor group were significantly higher than those in good group,while the serum APN level was significantly lower than that in good group(P<0.05,P<0.01).The AUC value of ROC curves of TG and LDL-C in predicting the short-term prognosis in patients with ACS was significantly smaller than that of FGF21,APN as well as FGF21 combined with APN prediction scheme,and the area under the curve(AUC)of FGF21 and APN was significantly smaller than that of the FGF21 combined with APN prediction scheme(P<0.05).The corresponding cut-off values of TG,LDL-C,FGF21 and APN were 1.94 mmol/L,3.10 mmol/L,2.39 ng/L and 6.96 mg/L,respectively.Conclusion Serum FGF21 and APN levels can effectively predict the short-term prognosis of ACS patients,and early clinical examination can provide intuitive and accurate evidence support for taking appropriate intervention measures as soon as possible,which is conducive to improving patient prognosis.
作者
王娟
魏琼
朱宇
孟路路
慧露露
马学敏
翟岩峰
WANG Juan;WEI Qiong;ZHU Yu;MENG Lu-lu;HUI Lu-lu;MA Xue-min;ZHAI Yan-feng(Department of Critical Care Medicine,the 983th Hospital of PLA Joint Logistics Support Forces,Tianjin 300142,China;Department of Anesthesiology,the 983th Hospital of PLA Joint Logistics Support Forces,Tianjin 300142,China)
出处
《解放军医药杂志》
CAS
2020年第9期44-48,共5页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
天津市科技计划项目(201504154)。
