摘要
目的探讨Cyclin E在甲状腺乳头状癌组织中的表达及其与临床病理特征的关系。方法用免疫组化SP法检测Cyclin E在甲状腺乳头状癌、甲状腺腺瘤及瘤旁正常甲状腺组织中的表达情况。结果 Cyclin E的阳性表达率在正常甲状腺组织、甲状腺腺瘤、甲状腺乳头状癌组织中逐渐升高(P<0.01)。Cyclin E表达与甲状腺乳头状癌的临床分期、周围组织浸润及淋巴结转移有关(P<0.01)。结论 Cyclin E的表达水平与甲状腺乳头状癌的发生、发展及预后有关,为甲状腺乳头状癌的治疗提供新的思路。
Objective To study the expression and clinical significance of Cyclin E in the thyroid gland papilliform tumor. Methods The expression of Cyclin E was tested by immunohistochemistry SP law of the thyroid gland papilliform tumor,the thyroid gland adenoma and the lump in the normal thyroid gland. Results The Cyclin E expression rate was elevated gradually( P<0. 01). Cyclin E expression was correlated with stages,peritonsillar tissue infiltration and lymph node shift related of thyroid gland papilliform tumor( P<0. 01). Conclusions Cyclin E expression level is correlated with the occurrence and development of thyroid gland papilliform tumor.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2014年第21期5951-5952,共2页
Chinese Journal of Gerontology
基金
国家自然科学基金面上项目(81272854)
黑龙江省自然科学基金项目(D201129)
