摘要
目的探讨S激酶相关蛋白2(Skp2)和P27kip1蛋白在非霍奇金淋巴瘤(NHL)患者病程中表达的临床意义及二者相关性。方法采用免疫组化SP染色法对42例NHL患者的Skp2和P27kip1蛋白进行检测,分析二者与临床预后的关系。结果单因素分析结果显示:全身症状、Ann-Arbor分期、国际预后指数(IPI)、ps评分、Skp2与P27kip1对NHL患者的总生存率有影响(P<0.05)。多因素分析结果显示:P27kip1、IPI、Ann-Arbor分期是NHL独立的预后因素(P<0.05)。Skp2和P27kip1蛋白在NHL患者病程中的表达呈负性相关(r=-0.381,P=0.013)。结论 P27kip1、IPI、Ann-Arbor分期对评估NHL患者的预后具有重要价值,可作为预测NHL临床疗效和判断预后的参考指标。
Objective To investigate the clinical significance of Skp2 and P27^kip1 protein expression in course of dis- ease of patients with non Hodgkin＇s lymphoma （NHL） and its relationship. Methods Immunohistoehemical SP staining method was used to detect Skp2 and P27^kip1 protein in 42 patients with NHL, and its correlation with clinical prognosis was analyszed. Results The results of single factor analysis showed that systemic symptoms, Ann-Arbor stage, international prognostic index （IPI）, ps score, Skp2 and P27~＇l had influences on overall survival rate of patients with NHL （P 〈 0.05）. Multivariate analysis showed that P27^kip1, IPI, Ann-Arbor stage were independent influence factors for NHL prognosis （P 〈 0.05）. Skp2 and P27^kip1 protein in the course of NHL expression were negatively correlated （r = -0.381, P = 0.013）. Conclusion P27^kip1, IPI, Ann-Arbor staging of patients with NHL have important value for patinets＇ prognostic evaluation, which can be used as indicators for NHL clinical curative effect and prognosis prediction.
出处
《中国医药导报》
CAS
2013年第10期14-16,共3页
China Medical Herald
