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广州市社区中老年女性维生素D水平与生活质量关系的调查研究 被引量:8

Study on the relationship between vitamin D level and quality of life in middle-aged and elderly women in Guangzhou community
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摘要 目的探讨广州市社区中老年女性维生素D水平与生活质量的关系。方法采用调查问卷现场对广州市社区1 199名45岁以上的女性进行调查,了解其基本资料(包括年龄、身高、腰围、臀围、跌倒史等)及EQ-5D量表对受试者生活质量进行评价。双能X线骨密度仪检测腰椎(L_(1-4))及左侧股骨近端的骨密度,收集受试者的血钙(Ca^(2+))、25-羟-维生素D[25(OH)D]、血清骨钙素(OC)、I型前胶原氨基末端前肽(PINP)、I型胶原羧基端肽β特殊序列(β-CTX)等,并测量受试者上、下肢肌力情况,据25(OH)D水平将受试者分为3组进行统计分析。结果血清25(OH)D平均水平为(26.8±6.5)ng/mL,其中维生素D缺乏占12.8%,维生素D不足占59.0%,维生素D充足仅占28.3%。与维生素D缺乏组比较,不足组和充足组在坐立试验时间、髋部骨密度以及β-CTX方面差异均有统计学意义(P<0.05),而不足组与充足组之间差异无统计学意义(P>0.05)。维生素充足组、不足组与缺乏组跌倒发生率分别为20.3%、21.3%、23.5%,依次增加,差异有统计学意义(P<0.05)。广州市社区中老年女性的生活质量总体评价较好,EQ-5D平均得分为0.803。其中行动能力、自理能力、日常活动三个维度的评价较好,满意率分别为91.8%、98.7%和93.8%,而在疼痛或不舒服以及焦虑或抑郁两个维度的评价则相对较差,满意率分别为60.1%和75.6%,维生素D充足组、不足组、缺乏组三组间的生活质量指数得分依次降低,差异有统计学意义(P<0.05)。结论中老年女性普遍存在维生素D不足或缺乏,可影响下肢肌力,加快骨转换,降低髋部骨密度,跌倒风险增加,从而影响其生活质量。 Objective To explore the relationship between vitamin D level and quality of life in middle-aged and elderly women in Guangzhou community.Methods A questionnaire survey was conducted on 1 199 women aged over 45 in Guangzhou community to understand their basic data(including age,height,waistline,hipline,history of falls,etc).The quality of life was evaluated with the EQ-5 D scale.Bone mineral density(BMD)of the lumbar spine(L1~4)and the left proximal femur was detected using dual-energy X-ray absorptiometry.Calcium,25-hydroxy vitamin D 25(OH)D,osteocalcin(OC),typeΙprocollagen amino-terminal peptide(PΙNP),beta typeΙcollagen carboxy-terminal peptide(β-CTX),and the muscle strength of the upper and lower limbs were measured.According to the 25(OH)D level,the subjects were divided into 3 groups for statistical analysis.ResultsThe mean level of serum 25(OH)D was(26.8±6.5)ng/mL.Among them,vitamin D deficiency accounted for 12.8%,vitamin D insufficiency accounted for 59%,and vitamin D sufficiency accounted for 28.3%only.Compared with vitamin D deficiency group,there were significant differences in the sitting test time,hip BMD,andβ-CTX in the insufficient and the sufficient group(P<0.05),but there was no significant difference between the insufficient and the sufficient group(P>0.05).The incidence of falls was 20.3%,21.3%,and 23.5%in vitamin adequacy group,insufficient group and deficient group,respectively(P<0.05).The overall evaluation of the quality of life of middle-aged and elderly women in Guangzhou community was better,and the average score of EQ-5 D was 0.803.Among them,the three dimensions of action ability,self-care ability,and daily activities were better,with satisfactory rates of 91.8%,98.7%,and 93.8%,respectively.But in terms of pain or discomfort and anxiety or depression,the two dimensions were relatively poor,with satisfactory rates of 60.1%and 75.6%,respectively.The scores of EQ-5 D in the three groups of vitamin D adequacy,insufficient,and deficient decreased in turn,and the difference was statist
作者 陈博来 杨立进 胡伟雄 林涌鹏 王拥军 CHEN Bolai;YANG Lijin;HU Weixiong;LIN Yongpeng;WANG Yongjun(Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510405,China;Guangzhou University of Chinese Medicine,Guangzhou 510405,China;The Affiliated Longhua Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
出处 《中国骨质疏松杂志》 CAS CSCD 北大核心 2019年第4期512-517,527,共7页 Chinese Journal of Osteoporosis
基金 国家中医临床研究基地业务建设第二批科研专项(JDZX2015081) 广东省中医院中医药科学技术研究专项(YN2016ZWB01) 广东省中医药重大疾病研究项目(20193007)
关键词 中老年女性 25羟维生素D 生活质量 EQ-5D middle-aged and elderly women 25(OH)D quality of life EQ-5D
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