摘要
目的探讨骨质疏松人群发生椎体压缩性骨折的早期,其骨代谢标志物的变化规律。方法对2013-06-2015-06采用保守治疗的100例此类患者进行骨代谢标志物检测,包括骨吸收标志物Ⅰ型胶原交联羧基末端肽(CTX),骨形成标志物Ⅰ型前胶原氨基末端前肽(PINP),以及血清钙、磷,25羟维生素D(25OHD),骨密度等指标。观察时间为骨折后1、2、3、5、8、12周。结果(1)PINP和CTX的变化规律:PINP自骨折后2周上升至高峰,直至第12周亦始终保持该水平;其CTX水平自第2周达到高峰,但其后即开始明显下降。(2)相关性分析。PINP与患者年龄呈负相关关系,与血磷、25OHD之间则均呈现显著的正相关关系(P<0.05);CTX仅与患者血磷呈直线相关关系(P=0.002)。结论骨质疏松人群发生椎体压缩骨折后,其骨代谢标志物CTX、PINP等的正常变化有一定规律可循,有利于评估其骨愈合的进程,对调整治疗方案、规避骨折不愈合或延迟愈合的风险,均有潜在的参考价值。
Objective To investigate the changes of bone metabolism markers in the early stage of osteoporotic vertebral compression fractures in the osteoporotic population. Methods From June 2013 to June 2015, the bone metabolic markers were detected in 100 cases with conservative treat- ment, including bone resorption markers of collagen cross-linked carboxy terminal peptide （CTX）, markers of type I procollagen amino terminal peptide （PINP） and bone formation, serum calcium, phosphorus, 25 hydroxy vitamin D （25OHD）, bone density index. The observation time was 1, 2, 3, 5, 8, 12 weeks after fracture. Results （1） The change rule of PINP and CTX： PINP increased from 2 weeks after fracture to the peak, and remained the same level until the twelfth week. The level of CTX reached peak from the second week, but it began to decrease obviously thereafter.（2） The correlation analysis showed that PINP was negatively correlated with age, and positively correlated with blood phosphorus and 25OHD （P〈0.05）; CTX was only linearly related to blood phosphorus in patients （P= 0.002）. Conclusion In patients with osteoporotic vertebral compression fractures, the changes of markers of bone metabolism such as CTX, PINP have some rules to follow, which are helpful to evalu- ate the bone healing process, adjust the treatment plan, avoid the risk of nonunion or delayed healing of fracture, it has reference potential.
出处
《颈腰痛杂志》
2017年第6期521-524,共4页
The Journal of Cervicodynia and Lumbodynia
关键词
骨质疏松
椎体压缩性骨折
骨代谢标志物
I型胶原交联羧基末端肽
I型前胶原氨基末端前肽
osteoporosis
vertebral compression fractures
markers of bone metabolism
type I collagen cross-linked carboxy terminal peptide
type I procollagen propeptide
