摘要
目的探讨趋化因子受体7(CCR7)与血管内皮生长因子-C(VEGF-C)的高表达与患者淋巴结转移与预后的关系。方法选取2014年3月至2015年9月间陕西核工业417医院收治的72例鼻咽癌患者的鼻咽癌组织为研究组,另选70例鼻咽黏膜组织正常者为对照组,比较两组组织CCR7和VEGF-C的表达情况,分析CCR7和VEGF-C指标与鼻咽癌患者临床特征及预后的关系。结果研究组患者鼻咽癌组织中CCR7和VEGF-C指标与对照组人员鼻咽黏膜组织比较,差异均有统计学意义(均P <0. 05)。研究组患者CCR7和VEGF-C指标表达与淋巴结转移有相关性(P <0. 05)。CCR7与VEGF-C呈正相关(r=0. 89,P <0. 05)。CCR7低表达者3年存活率为80. 0%(24/30),高于高表达者的26. 2%(11/42); VEGF-C低表达者3年存活率为82. 1%(23/28),高于高表达者的15. 9%(7/44),差异均有统计学意义(均P <0. 05)。结论 CCR7和VEGF-C指标高表达与鼻咽癌患者淋巴结转移及预后有关,可作为判断鼻咽癌患者淋巴结转移与预后的重要指标。
Objective To study the relationship between the abnormal overexpression of chemokine receptor 7( CCR7) and vascular endothelial growth factor-C( VEGF-C) and lymph node metastasis and prognosis in patients with nasopharyngeal carcinoma. Methods A total of 72 patients with nasopharyngeal carcinoma admitted to 417 Hospital of Shaanxi Nuclear Industry from March 2014 to September 2015 were selected as the study group,and 70 individuals with normal nasopharyngeal mucosa were selected as the control group. The expression of CCR7 and VEGF-C were compared between the two groups,and the relationship between CCR7,VEGF-C and clinical characteristics and prognosis were analyzed. Results There was significant difference in the expression of CCR7 and VEGF-C between the two groups( P < 0. 05). The expression of CCR7 and VEGF-C was associated with lymph node metastasis( P < 0. 05). CCR7 was positively related to VEGF-C( P < 0. 05). Three year survival was 80. 0%( 24/30) in patients with low expression of CCR7 which was higher than 26. 2%( 11/42) in patients with high expression of CCR7. The3-year survival was 82. 1%( 23/28) in patients with low expression of VEGF-C which was higher than15. 9%( 7/44) in patients with high expression of VEGF-C( all P < 0. 05). Conclusion The high expression of CCR7 and VEGF-C was associated with lymph node metastasis and prognosis. It could be used as an important index to judge the lymph node metastasis and prognosis in nasopharyngeal carcinoma.
作者
孙国义
吴宝俊
詹红星
SUN Guo-yi;WU Bao-jun;ZHAN Hong-xing(Department of Otolaryngology,417 Hospital of Shaanxi Nuclear Industry,Xi'an 710600,China;Department of Otolaryngology,Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Otolaryngology,Tangcheng Hospital,Xi'an 710600,China)
出处
《中国肿瘤临床与康复》
2019年第3期272-275,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
趋化因子受体7
血管内皮生长因子-C
鼻咽肿瘤
淋巴转移
Chemokine receptor 7
Vascular endothelial growth factor-C
Nasopharyngeal neoplasms
Lymphatic metastasis
