摘要
药物不良反应(ADR)是导致患者发病率、病死率升高以及公共卫生资源浪费的重要因素,是人类健康的一大负担。由年龄引起的药物代谢动力学以及药效学上的变化,使得ADR在老年群体中时有发生,表现为胃肠道疾病、低血糖、摔倒、直立性低血压、谵妄以及肾功能衰竭等临床症状。老年人因ADR而入院的主要危险因素有年龄、多种类用药、共患病以及潜在不合理用药。目前,针对老年患者已有一些ADR预测的工具,可通过对老年患者进行相关因素的风险评估,从而达到预防不良反应的作用。本文对老年患者ADR的特征以及ADR预测模型的研究进展进行了综述。
Adverse drug reaction(ADR)leads to high morbidity and mortality,waste of public health resources and increased burden of human health.ADR is common in elderly patients due to age-induced changes in pharmacokinetics and pharmacodynamics,manifesting as gastrointestinal lesion,hypoglycemia,falling,orthostatic hypotension,delirium and renal failure.Advanced age,polypharmacy,comorbidities and inappropriate medication are risk factors of ADR.Predicting tools or models for ADR are valuable in risk assessment and prevention.This paper reviewed the research progress of characteristics and predicting tools of ADR in elderly patients.
作者
陈静
周峥
Chen Jing;Zhou Zheng(Department of Pharmacy,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310018,China)
出处
《中国医药》
2019年第5期798-800,共3页
China Medicine
