摘要
目的研究艾蒿Artemisia argyi的化学成分。方法采用溶剂萃取、硅胶柱色谱、高效液相色谱等方法进行分离纯化,通过理化性质及波谱数据分析鉴定结构。结果从艾蒿中分离得到34个化合物,分别鉴定为5-羟基-6,7,3′,4′-四甲氧基黄酮(1)、半齿泽兰素(2)、对羟基苯乙酮(3)、覆盆子酮(4)、姜酮(5)、7-羟基香豆素(6)、对羟基苯甲酸(7)、脱氢去乙酰氧母菊素(8)、3α-羟基-1(10),4,11(13)-吉马三烯-12,6α-内酯(9)、棕矢车菊素(10)、7-羟基松油醇(11)、顺-2,8-二羟基-对薄荷-1(7)-烯(12)、反-2,8-二羟基-对薄荷-1(7)-烯(13)、艾黄素(14)、东莨菪内酯(15)、艾蒿内酯C(16)、去乙酰母菊酮素(17)、1-表-4,5-二氢灰蒿素C(18)、11,13-脱氢去乙酰母菊酮素(19)、1,9-壬二酸(20)、3-methoxy-tanapartholide(21)、红花菜豆酸(22)、断愈创木酸(23)、5,3′,4′-三羟基-6,7-二甲氧基黄酮(24)、1,7-庚二酸(25)、10-epi-ajafinin(26)、3-epi-iso-seco-tanapartholide(27)、austroyunnane C(28)、刘寄奴内酯(29)、川芎内酯A(30)、seco-tanapartholide B(31)、3-dehydroxy-iso-seco-tanapartholide(32)、3α-hydroxyreynosin(33)、二氢红花菜豆酸(34)。结论化合物4、22、25、30、33、34为首次从蒿属植物中分离得到,化合物5、7、8、11～13、21、23、24、26～28为首次从艾蒿中分离得到。
Objective To study the chemical constituents of Artemisia argyi.Methods The chemical constituents were isolated by silica gel column chromatography and HPLC,and its structure were identified by their spectral data and physicochemical properties analysis.Results Thirty-four compounds were isolated from A.argyi with the structures identified as 5-hydroxy-6,7,3′,4′-tetramethoxyflavone(1),eupatorin(2),p-hydroxy-acetophenone(3),raspberry ketone(4),zingiberone(5),7-hydroxycoumarin(6),p-hydroxybenzoic acid(7),desacetoxymatricarin(8),3α-hydroxy-1(10),4,11(13)-triene-12,6α-olide(9),jaceosidin(10),7-hydrxyterpineol(11),cis-2,8-dihydroxy-p-mentha-1(7)-en(12),trans-2,8-dihydroxy-p-mentha-1(7)-en(13),artemisetin(14),scopoletin(15),arteminolide C(16),desacetylmatricarin(17),artecalin(18),11,13-dehydrodesacetylmatricarin(19),1,9-azelaic acid(20),3-methoxy-tanapartholide(21),phaseic acid(22),seco-guaiaretic acid(23),5,3′,4′-trihydroxy-6,7-dimethoxy-flavone(24),1,7-pimelic acid(25),10-epi-ajafinin(26),3-epi-iso-seco-tanapartholide(27),austroyunnane C(28),artanomaloide(29),ligustolide A(30),seco-tanapartholide B(31),3-dehydroxy-iso-seco-tanapartholide(32),3α-hydroxyreynosin(33),dihydrophaseic acid(34).Conclusion Compounds 4,22,25,30,33,34 are separated from the Artemisia for the first time.Compounds 5,7,8,11—13,21,23,24,26—28 are isolated from A.argyi for the first time.
作者
张树军
马耀玲
王金兰
李军
赵明
白丽明
ZHANG Shu-jun;MA Yao-ling;WANG Jin-lan;LI Jun;ZHAO Ming;BAI Li-ming(School of Chemistry and Chemical Engineering,Qiqihar University,Qiqihar 161006,China)
出处
《中草药》
CAS
CSCD
北大核心
2019年第8期1906-1914,共9页
Chinese Traditional and Herbal Drugs
基金
黑龙江省教育厅基本业务专项理工重点项目(135209101)
关键词
艾蒿
倍半萜
覆盆子酮
姜酮
脱氢去乙酰氧母菊素
红花菜豆酸
断愈创木酸
Artemisia argyi Lévl.et Vant.
sesquiterpenoids
raspberry ketone
zingiberone
desacetoxymatricarin
phaseic acid
seco-guaiaretic acid
