摘要
目的研究海南粗榧Cephalotaxus hainanensis的生物碱类成分。方法采用硅胶、Sephadex LH-20和ODS等多种柱色谱技术进行分离纯化,根据化合物理化性质及波谱数据鉴定化合物结构。结果从海南粗榧总碱中分离得到13个化合物,分别鉴定为三尖杉碱(1)、异三尖杉酮碱(2)、三尖杉酮碱(3)、三尖杉胺G(4)、(2R,3S,4S,5S)-2,3-二羟基三尖杉碱(5)、乙酰三尖杉碱(6)、脱氧三尖杉酯碱(7)、(R)-丽江三尖杉碱(8)、(S)-丽江三尖杉碱(9)、3-表里哈灭里辛碱异构体(10)、1,4-N-二异丙胺蒽醌(11)、苯甲酸(2-乙基)-正己酯(12)和β-谷甾醇(13)。结论化合物3~6和10~13为首次从海南粗榧中分离得到。
Objective To study the alkaloids constituents from Cephalotaxus hainanensis.Methods The column chromatography Sephadex LH-20 and ODS were used to isolate and purify the compounds of alkaloids part of C.hainanensis.The chemical structures were identified on basis of physicochemical properties and spectral data.Results Thirteen compounds were isolated and identified as cephalotaxine(1),isocephalotaxinone(2),cephalotaxinone(3),cephalezomine G(4),(2 R,3 S,4 S,5 S)-2,3-dihydroxycephalotaxane(5),acetylcephalotaxine(6),deoxyharringtonine(7),(R)-fortunine(8),(S)-fortunine(9),isomer of 3-epi-schellhammericine(10),1,4(PrINH)2-anthraquinone(11),2-ethyl-n-hexyl benzoate(12),andβ-sitosterol(13).Conclusion Compounds 3—6 and 10—13 are isolated from this plant for the first time.
作者
于淼
黄圣卓
张宇
王昊
梅文莉
曲有乐
戴好富
YU Miao;HUANG Sheng-zhuo;ZHANG Yu;WANG Hao;MEI Wen-li;QU You-le;DAI Hao-fu(Jiamusi University,Jiamusi154007,China;Key Laboratory of Biology and Genetic Resources of Tropical Crops,Ministry of Agriculture,Institute of Tropical Bioscienceand Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou571101,China)
出处
《中草药》
CAS
CSCD
北大核心
2019年第7期1541-1545,共5页
Chinese Traditional and Herbal Drugs
基金
海南省自然科学基金创新研究团队项目(2017CXTD020)
中国热带农业科学院基本科研业务费专项资金(17CXTD-15
1630052016008)
现代农业产业技术体系建设专项资金项目(CARS-21)
