摘要
阿尔茨海默病(Alzheimer’sdisease,AD)是造成老龄人口认知能力减退的主要疾病之一。芍药苷是毛茛科(Ranunculaceae)植物芍药Paeonia lactiflora或牡丹Paeonia suffruticosa根皮中提取出的水溶性单萜苷,具有改善认知能力、镇静、抗炎、镇痛、解痉等作用,可以有效调节AD动物及细胞模型异常磷酸化的Tau蛋白和过度沉积的β-淀粉样蛋白(Aβ)水平,恢复乙酰胆碱、神经生长因子、Ca2+、α7烟碱样乙酰胆碱受体和腺苷受体等神经递质及神经受体的平衡状态,降低组织炎症反应和氧化应激反应并减少细胞凋亡的发生。对近10年来国内外有关芍药苷干预AD的研究进展进行综述,为探索中药防治AD研究提供理论依据。
Alzheimer’s disease(AD)is one of the main pathogenies of the cognitive decline in aging population.Paeoniflorin is a water-soluble monoterpene isolated from the roots of Paeonia lactiflora or P.suffruticosa,which are both in the family Ranunculaceae.Paeoniflorin has the effect of improving the cognitive ability,sedative,anti-inflammatory,analgesic,and spasmolytisch activities.It could also regulate hyperphosphorylation of Tau and Aβproteins;Paeoniflorin can restore the balance of neurotransmitter and neurotransmitter receptors including acetylcholine,nerve growth factor,calcium ion,α7 nicotinic acetylcholine receptor and adenosine receptors,and reduce inflammation,oxidative stress and neuron apoptosis in AD animal and cell models.This paper reviewed relevant research in the past decade about the effect of paeoniflorin on AD,which may provide theoretical basis to use agent from Chinese medicine for AD prevention and treatment.
作者
邢敏
毛敬洁
陈文列
林炜
王静楠
XING Min;MAO Jing-jie;CHEN Wen-lie;LIN Wei;WANG Jing-nan(Academy of Integrated Chinese and Western Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Fujian Key Laboratory of Integrative Medicine on Geriatrics,Fuzhou 350122,China;School of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China)
出处
《中草药》
CAS
CSCD
北大核心
2019年第4期1022-1026,共5页
Chinese Traditional and Herbal Drugs
基金
福建省科技厅自然科学基金项目(2017J01847)
关键词
阿尔茨海默病
芍药苷
中药单体
Β-淀粉样蛋白
TAU蛋白
Alzheimer’s disease
paeoniflorin
Chinese materia medica monomer
amyloidβ-protein
Tau protein
