摘要
目的 :探讨胰肾联合移植尸体移植物的切取、修剪方法和移植治疗Ⅱ型糖尿病合并肾功能衰竭的临床效果 .方法 :对 7例尸体供者均采用原位低温灌注、整块切取后体外修剪的方法获得可供移植的胰腺、十二指肠和肾脏 .1例Ⅱ型糖尿病合并肾功能衰竭患者接受胰肾联合移植 ,肾脏移植于左髂窝 ,胰腺移植于右髂窝 ,胰腺外分泌经膀胱引流 .结果 :热缺血时间平均 3min ,修剪时间平均 2h .其中用于临床胰肾联合移植的移植物 ,移植肾功能 2d恢复正常 ,移植胰功能3d恢复正常 ,患者血糖在正常范围 ,不需控制饮食 ,也不需要应用胰岛素 ;另 6例肾脏用于临床移植 ,移植肾功能恢复良好 ,胰腺用于分离胰岛细胞 ,胰岛细胞存活率达到 90 % ,纯度达到 70 % .结论
AIM: To discuss the harvesting and trimming of combined pancreas and kidney grafts from cadaveric donors and to examine the clinical outcome of typeⅡ diabetes with renal failure treated with simultaneous pancreas and kidney transplantation. METHODS: Pancreas, duodenum and kidney grafts were obtained with methods of hypothermia perfusion in situ and whole piece harvesting in 7 cases of cadavers. The simultaneous pancreas kidney transplantation was performed in 1 case which was diagnosed as type Ⅱ diabetes with renal failure. Renal allograft was placed in the left iliac fossa, whereas pancreas allograft in the right iliac fossa with pancreas exocrine drainage to bladder. RESULTS: The average warm ischemia time was 3 minutes. The average trimming time was 2 hours. The function of kidney and pancreas grafts recovered to normal in 2 days and 3 days after simultaneous pancreas kidney transplantation,respectively. Fasting blood glucose was normal without diet control and insulin. The function of another 6 kidney allografts recovered well after operation. The function of another 6 pancreas allografts were separated into islets of Langerhans. The survival rate and purity of islets were 90% and 70%,respectively. CONCLUSION: Our technique of harvesting combined pancreas and kidney grafts is fitted for cadaveric donors.
出处
《第四军医大学学报》
CAS
北大核心
2003年第20期1893-1895,共3页
Journal of the Fourth Military Medical University
基金
陕西省科技研究发展计划科技攻关项目 (2 0 0 1K1 0 G8)
关键词
移植
胰腺切除术
肾切除术
transplantation
pancreatectomy
nephrectomy
