摘要
目的 探讨活体小肠移植受体术后抗急性排斥反应的治疗经验 .方法 18岁短肠综合征患者接受活体小肠移植 ,按 FK5 0 6+骁悉 ( MMF) +强的松龙联合用药方案给予免疫抑制治疗 .结果 术后一度平稳 ,手术 1mo后药物减量 ,60 d出现排斥反应现象 ,给予大剂量免疫抑制剂冲击治疗 .治疗 3 d后症状消失 ,至今移植肠功能良好 .结论 小肠移植术后的抗免疫排斥治疗药物不宜过早减量 ,我们采用的抗急性排斥反应的治疗方案是成功而有效的 .
AIM To report the experience in management of posttransplant immunosuppression of the clinical living related small bowel transplantation. METHODS An 18 year old boy with short gut syndrome underwent the living related small bowel transplantation. The posttranplant immunosuppession was initially with Tacrolimus, mycophenolatemofetil (MMF), and prednisone. RESULTS After operation the recipient was in good condition. About 60 days, he showed some signs of acute reject reaction, but after treatment of large dose immunosuppression, the symptoms disappeared after 3 days and the function of transplant gut was good up to now. CONCLUSION The posttransplant immunosuppression is successful, but weakening the treatment dose of immunosppression may be improper in early stage of intestinal transplantation.
出处
《第四军医大学学报》
北大核心
2001年第13期1198-1199,共2页
Journal of the Fourth Military Medical University
关键词
小肠移植
活体供者
排斥反应
免疫治疗
small bowel transplantation
living donors
rejection
immunotherapy
