摘要
目的 :综合评价HBV宫内传播发生的危险因素 .方法 :应用Meta分析的固定效应和随机效应模型 ,针对 6篇有关HBV宫内传播危险因素的病例对照研究进行综合分析 ,共累计病例 2 93例 ,对照 1 30 3例 .结果 :孕妇HBVDNA阳性、HBeAg阳性、先兆早产、先兆流产、Apgar低分、剖宫产等 6个研究因素的合并OR值分别为 1 5 7.5 9(1 7.6 4～ 1 4 0 8.1 0 )、1 4 .0 1(7.1 0～ 2 4 .1 6 )、4 .6 3(1 .33～ 1 6 .0 9)、0 .73(0 .2 6～ 2 .0 1 )、1 .1 8(0 .39～ 3.5 6 )、1 .0 1 (0 .5 9～ 1 .75 ) .结论 :孕妇HBVDNA阳性、HBeAg阳性是宫内感染发生的高危因素 ;先兆早产与宫内感染的发生呈中等程度相关 ;先兆流产、Apgar低分、剖宫产与宫内感染的发生关联相对不明显 。
AIM: To evaluate the risk factors of HBV intrauterine transmission. METHODS: Meta analysis was used to explore the data from 6 published papers in order to make formal summary statements about the risk factors of HBV intrauterine transmission. Fixed effect model and random effect model were applied to process these data. The cumulative cases and controls were 293 and 1303 respectively. RESULTS: The pooled OR of HBV DNA positive, HBeAg positive, threatened premature labor, threatened abortion, Apgar score in 5 min<7, caesarean birth were 157.59(17.64～1408.10)、14.01(7.10～27.66)、4.63 (1.33～ 16.09)、0.73(0.26～2.01)、1.18(0.39～3.56)and 1.01(0.59～1.75)respectively. CONCLUSION: HBV DNA and HBeAg positive in pregnancy womens sera might serve as the most important risk factors of HBV intrauterine transmission. The history of threatened premature labor also has a significant association with HBV intrauterine transmission. The effect of exposure to threatened abortion, Apgar score < 7 in 5 min, caesarean birth on HBV intrauterine transmission was uncertain in this study which calls for further investigation.
出处
《第四军医大学学报》
北大核心
2003年第24期2290-2292,共3页
Journal of the Fourth Military Medical University
基金
国家自然科学基金重点资助项目 ( 30 2 30 32 0 )
关键词
肝炎
乙型
宫内传播
危险因素
META分析
hepatitis B
intrauterine transmission
risk factors
Meta analysis
