摘要
目的探讨阿托伐他汀联合氯吡格雷治疗初发急性缺血性脑卒中患者的疗效,及对患者预后的影响,为临床治疗提供参考。方法选取2016年2月—2017年7月中山市三乡镇社区卫生服务中心收治的90例急性缺血性脑卒中患者为观察对象,以随机数字表法分为观察组和对照组,每组45例。对照组予以氯吡格雷联合阿司匹林,观察组在对照组的基础上予以阿托伐他汀治疗,均持续治疗1个月。观察并比较两组疗效及治疗前后神经功能缺损评分(NIHSS)和自理能力指数(Barthe),检测并比较治疗前后血清同型半胱氨酸(Hcy)、超敏C-反应蛋白(hs-CRP)水平以及预后情况等方面的差异。结果观察组的总有效率为91.11%,明显高于对照组的71.11%,差异有统计学意义(P<0.05)。治疗前,两组NIHSS和Barthel指数比较,差异无统计学意义(P>0.05);治疗后,观察组NIHSS评分明显低于对照组,而Barthel指数明显高于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清Hcy和hs-CRP水平比较,差异无统计学意义(P>0.05);治疗后,观察组血清Hcy和hs-CRP水平明显低于对照组,差异均有统计学意义(均P<0.05)。观察组复发率、出血率、病死率均明显低于对照组,差异有统计学意义(均P<0.05)。结论阿托伐他汀联合氯吡格雷治疗急性缺血性脑卒中患者的疗效显著,有利于促进患者神经功能以及日常生活活动能力的恢复。
Objective To explore the effect and prognosis of atorvastatin combined with clopidogrel on patients with acute ischemic stroke. Methods Ninety patients with acute ischemic stroke were selected from February 2016 to July 2017 and divided into the observation group and the control group by random number table, 45 cases in each group. The control group was given clopidogrel combined with aspirin, and the observation group was treated with atorvastatin on the basis of the control group.Results The total effective rate of the observation group was significantly higher than that of the control group(91.11% vs. 71.11%, P<0.05). After treatment, the NIHSS score of the observation group was significantly lower than that of the control group;the Barthel index was significantly higher than that of the control group(P<0.05). After treatment, the serum Hcy and hs-CRP levels in the observation group were significantly lower than those in the control group(P<0.05). The recurrence rate, bleeding rate and mortality rate of the observation group after treatment were significantly lower than those of the control group(P<0.05). Conclusion Atorvastatin combined with clopidogrel has a significant effect for acute ischemic stroke patients, and it is conducive to promoting the recovery of neurological function and daily life activity ability.
作者
陈运聪
黄翔
潘赞前
CHEN Yun-cong;HUANG Xiang;PAN Zan-qian(The Centre of Community Health Service of Sanxiang Town,Zhongshan,Guangdong 528463,China)
出处
《慢性病学杂志》
2019年第2期177-180,共4页
Chronic Pathematology Journal
