摘要
目的 分析联合采用阿托伐他汀及阿司匹林治疗急性缺血性脑卒中对炎性因子、颈动脉斑块及神经功能缺损程度的影响.方法 选取2015年2月至2015年5月78例急性缺血性脑卒中患者,根据用药方案不同分为对照组和研究组,每组39例.对照组仅采用阿司匹林,研究组联合采用阿司匹林与阿托伐他汀.对比治疗前后两组神经功能缺损程度（NIHSS）评分及日常生活活动能力（BI）评分、血脂指标[低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、总胆固醇（TC）、三酰甘油（TG）]水平、炎性因子[超敏C-反应蛋白（hs-CRP）、脂蛋白相关磷脂酶A2（Lp-PLA2）及氧化型低密度脂蛋白（ox-LDL）]水平、颈动脉斑块面积与狭窄率变化情况,6个月后随访,统计两组疾病复发率.结果 治疗前两组NIHSS评分及BI评分比较差异未见统计学意义（P〉0.05）;治疗后,研究组各指标评分优于对照组,差异有统计学意义（P〈0.05）.治疗前两组TG、TC、HDL-C、LDL-C、hs-CRP、Lp-PLA2及ox-LDL水平、颈动脉斑块面积与狭窄率比较差异未见统计学意义（P〉0.05）;治疗后,研究组各指水平优于对照组,差异有统计学意义（P〈0.05）.研究组疾复发率（2.56%）低于对照组（20.51%）,差异有统计学意义（P〈0.05）.结论 联合应用阿托伐他汀及阿司匹林治疗急性缺血性卒中疗效确切,可显著改善患者血脂、炎性因子及颈动脉斑块水平,改善其神经功能及日常生活活动能力,降低疾病复发率.
Objective To analyze the effects of atorvastatin and aspirin on inflammatory factors, carotid artery plaque and the degree of neurological impairment in patients with acute ischemic stroke.Methods Seventy-eight patients with acute ischemic stroke from February 2015 to May 2015 were selected.According to the different treatment plan, they were divided into control group （n=39） and study group （n=39）.The control group was only treated with aspirin, the study group was treated with aspirin and atorvastatin.The neural function defect degree （NIHSS） and activities of daily living （BI） score, blood lipid indexes of low density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C）, total cholesterol （TC）, triacylglycerol （TG）, inflammatory factor [high sensitive C-reactive protein （hs-CRP）, lipoprotein associated phospholipase A2 （Lp-PLA2） and oxidized low density lipoprotein （ox-LDL）] levels and carotid artery plaque area were compared between the two groups before and after treatment.And the stenosis rate changes were followed up after 6 months, and the disease recurrence rate of the two groups were analyzed.Results The NIHSS score and BI score had no significant difference between the two groups before treatment （P〉0.05）;after treatment the NIHSS score and BI score were better than those in the control group, the differences were significant （P〈0.05）.The TG, TC, HDL-C, LDL-C, hs-CRP, Lp-PLA2 and ox-LDL levels, carotid plaque area and the stenosis rate of contrast had no significant difference between the two groups before treatment（P〉0.05）;After treatment, the levels of above indexes in the study group were better than those in the control group, the differences were significant （P〈0.05）.The recurrence rate （2.56%） in the study group was lower than that in the control group （20.51%）, and the difference was significant （P〈0.05）.Conclusions The combination of atorvastatin and aspirin therapy is effective on acute i
出处
《中国实用医刊》
2017年第9期32-35,共4页
Chinese Journal of Practical Medicine
