摘要
目的探讨氯吡格雷联合低分子肝素钙治疗进展性缺血性脑卒中的有效性及安全性。方法选取2014年3月~2016年12月在我院接受治疗的96例进展性缺血性脑卒中患者为研究对象,采用随机数字法分为观察组和对照组,各48例,对照组采用低分子肝素钙治疗,观察组在对照组基础上使用氯吡格雷,比较两组的疗效、治疗前后神经功能缺损评分(NIHSS)及患者血浆黏度、纤维蛋白原、血小板聚集率等血流动力学指标变化,观察不良反应。结果观察组的总有效率为93.75%,显著高于对照组的79.17%,差异有统计学意义(P<0.05);治疗后,观察组的NIHSS评分显著低于对照组,差异有统计学意义(P<0.05);血流动力学方面,观察组治疗后的血浆黏度、纤维蛋白原、血小板聚集率等指标均显著优于对照组,差异有统计学意义(P<0.05);两组患者治疗后的总不良反应发生率比较,差异无统计学意义(P>0.05)。结论氯吡格雷联合低分子肝素钙治疗进展性缺血性脑卒中的效果明显,安全性高,临床上具有较高的应用价值。
Objective To investigate the efficacy and safety of Clopidogrel combined with Low Molecular Weight Hep- arin Calcium in the treatment of progressive ischemic stroke.Methods 96 patients with progressive isehemic stroke who were treated in our hospital from March 2014 to December 2016 were selected and randomly divided into the observa- tion group and the control group,each group had 48 eases.The control group was treated with Low Molecular Heparin Calcium,while the observation group was treated with Clopidogrel on the basis of the control group.And the curative ef- fects,neurological deficit score （NIHSS） and the changes of plasma viscosity,fibrinogen,platelet aggregation rate and oth- er hemodynamic parameters before and after treatment of the two groups were compared.Then the adverse reactions of the two groups were observed.Results The total effective rate of the observation group was 93.75%,and it was signifi- cantly higher than that of the control group （79.17%）,and the difference was statistically significant （P〈0.05）.NIHSS of the observation group was significantly lower than that of the control group after the treatment,and the difference was statistically significant （P〈0.05）.In terms of hemodynamies,the plasma viscosity,fibrinogen and platelet aggregation rate in the observation group were significantly lower than those in the control group,and the difference was statistically sig- nificant （P〈0.05）.there was no significant difference in the total incidence rate of adverse reactions between the two groups after treatment （P〉0.05）.Conclusion Clopidogrel combined with Low Molecular Weight Heparin Calcium in the treatment of progressive ischemie stroke is effective and safe,and it has a higher application value in clinic.
出处
《中国当代医药》
2017年第11期134-136,共3页
China Modern Medicine
关键词
氯吡格雷
低分子肝素钙
进展性缺血性脑卒中
有效性
安全性
Clopidogrel
Low Molecular Weight Heparin Calium
Progressive ischemic stroke
Efficacy
Safety
