摘要
目的探讨精神分裂症超高危人群(UHP)与健康被试(HC)的认知功能的差异。方法选择40例UHP人群及40例HC被试,采用连线测试、词汇流畅性、威斯康辛卡片分类测试(WCST)评估两组认知功能差异。结果与HC组比较,UHP组在连线测试B耗时较长[(91.65±27.17)vs.(102.43±18.62)s]、WCST正确应答数较低[(65.93±5.07)vs.(63.10±6.20)次],差异有统计学意义(t=-2.069,P=0.042;t=2.231,P=0.029);UHP组与HC组在词汇流畅性方面,差异无统计学意义[(12.15±2.52)vs.(12.67±2.11)分,t=-0.991,P=0.325]。结论 UHP人群存在认知功能的损伤,可能与中枢功能异常有关。
Objective To explore the difference of cognitive function between ultra high risk of psychosis(UHP) subjects and health controls(HC). Methods A total of 40 UHP subjects and 40 HC were selected and compared. Cognition function of all the subjects were assessed by Trail Making Test, Verbal fluency test, Wisconsin Card Sorting Test(WCST). Results Compared with HC group, UHP group showed signiflcantly longer time in performance of Trail Making Test-B [(91.65±27.17) vs.(102.43 ± 18.62) s, t=-2.069, P=0.042] and less replies correct number of WCST[(65.93 ± 5.07) vs.(63.10 ± 6.20), t=2.231, P=0.029]. There were no signiflcant difference between UHP group and HC group in Verbal fluency test [(12.15±2.52) vs.(12.67±2.11), t=-0.991, P=0.325]. Conclusion UHP patients have impairment of cognition function, which might be attributed to the dysfunction of the central nervous system.
出处
《慢性病学杂志》
2017年第7期737-739,共3页
Chronic Pathematology Journal
关键词
精神分裂症
认知功能
超高危
Schizophrenia
Cognition function
Ultra high risk
