摘要
目的:探讨首发精神分裂症患者、高危人群及超高危人群的认知功能特点。方法:收集符合美国精神疾病诊断与统计手册第4版(DSM-Ⅳ)的首发精神分裂症患者(41例)、符合精神病风险综合征(SIPS)诊断标准的超高危人群(25例)、精神分裂症患者的非精神病一级亲属(31例)、健康人群(27例),采用连线测验(TMTA)、符号编码、霍普金斯词语学习测验修订版(HVLT)、持续操作测验(CPT)、Stroop色词测验进行认知功能测评。结果:四组人群在连线测验(F=11.45,P<0.001)、符号编码(F=11.69,P<0.001)、HVLT-R(F=5.34,P<0.05)、Stroop单字(F=2.79,P<0.05)、Stroop单色(F=3.73,P<0.05)、Stroop色词(F=3.83,P<0.05)及CPT测验(F=13.62,P<0.05)中差异均有统计学意义。患者一级亲属和超高危人群认知功能介于首发精神分裂症患者和健康人群之间,且患者一级亲属要好于超高危人群(Ps<0.05)。结论:精神分裂症的患者一级亲属、超高危个体以及首发精神分裂症患者的认知功能损害依次加重,提示认知损害的程度与患病风险相关。
Objective： To explore the characteristics of cognitive function in first episode patients （FES）, ul- tra-high risk subjects （UHRs） and non-psychotic first-degree relatives of schizophrenia （FDRs）, in comparison with healthy controls （HCs）. Methods： Forty-one FES patients which met the Diagnostic and Statistical Manual of Men- tal Disorders, the Fourth＇Edition （DSM-IV） criteria for schizophrenia, 31 UHRs which met the Structured Interview for Psychosis-risk Syndromes （SIPS）, 25 FDRs of patients with schizophrenia （unrelated to the FES group）, and 27 HCs were recruited. They were assessed with the connection test （TMTA）, symbol coding, hopkins verbal learning test revision （HVLT）, continuous performance test （CPT）, and Stroop color-word test for evaluation of cognitivefunction. Results： After controlling for basic demographic characteristics including age, gender and educational lev- el, there was a significant difference between FES, FDRs, UHRs and HCs with respect to TMTA （ F = 11.45, P 〈 0.001）, symbol encoding （ F = 11.69, P 〈 0.001）, HVLT-R（ F = 5.34, P 〈 0.05）, Stroop word test （ F = 2.79, P 〈 0. 05）, Stroop color test F = 3.73, P 〈 0. 05）, Stroop color-word test （ F = 3.83, P 〈 0. 05） and the CPT test （ F = 13.62, P 〈0. 05）. FES patients performed worse than FDRs, UHRs, or HCs. FDRs performed better than UHRs in the following tests （Ps 〈 0. 05）. Conclusion： The severity of cognitive impairments is associated with the risk of de- veloping schizophrenia.
作者
张哲
周福春
何凡
杨宁波
张梁
王传跃
ZHANG Zhe ZHOU Fu-Chun HE Fan YANG Ning-Bo ZHANG Liang WANG Chuan-Yue(Bcijing Anding Hospital, Capital Medical University, Department of Psychiatry, Beijing Key Laboratory of Mental Disorders, Cen- ter of Schizophrenia, Beijing Institute for Brain Disorders and Laboratory of Brain Disorders（Capital Medical University）, Ministry of Science and Technology, Beijing 100088, China Longquan Hospital, Mentougou District, Beijing 102300, China)
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2017年第5期345-349,共5页
Chinese Mental Health Journal
基金
国家自然基金面上项目(81471365)
卫生行业科研专项(201002003)
北京市科技计划项目(D121100005012004)
北京市医院管理局临床医学发展专项经费资助(ZYLX201403)
关键词
首发精神分裂症
认知功能
患者一级亲属
超高危
first episode schizophrenia
cognitive functions
first-degree relatives of schizophrenia
Ultrahigh risk for psychosis
