摘要
目的观察和分析高血压患者中幽门螺杆菌(Hp)感染引起胃蛋白酶原(PG)改变及其临床意义。方法选取60例高血压患者作为研究对象,根据其是否为Hp感染将其分为Hp感染组(32例)和非Hp感染组(28例),对两组患者的血压、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、胃蛋白酶原Ⅰ/Ⅱ(PGⅠ/Ⅱ)比值、合并高血压肾病情况、合并视网膜病变情况进行观察和比较。采用SPSS13.0统计软件进行统计分析,计量资料用均数±标准差(xˉ±s)表示,采用t检验,计数资料用率(%)表示,采用χ~2检验,P<0.05表示差异有统计学意义。结果 Hp感染组患者的血清TG水平、血清TC水平均显著高于非Hp感染组(t=3.264、3.853,P<0.05),而PGⅠ/Ⅱ比值显著低于非Hp感染组(t=-5.159,P<0.05);两组中合并高血压肾病或视网膜病变的患者的PGⅠ/Ⅱ比值均显著低于未合并高血压肾病或视网膜病变的患者(t=2.754、2.963、3.022、3.267,P<0.05);PGⅠ/Ⅱ比值诊断高血压患者肾病和视网膜病变的血药浓度-时间曲线下面积(AUC)分别为0.774和0.883(P<0.05)。结论 Hp感染可导致高血压患者出现显著降低的PGⅠ/Ⅱ比值,该指标对患者合并高血压肾病、视网膜病变的发病具有提示作用,具有较高的诊断效能,可作为早期诊断的辅助指标。
Objective To observe and analyze the change of pepsinogen(PG) caused by the infection of Helicobacter pylori(Hp) in patients with hypertension and its clinical significance. Methods 60 cases of patients with hypertension were selected as the research subjects and divided into the Hp infection and control group without Hp infection. There were 32 and 28 cases in the infection and control group, respectively. The blood pressure, total cholesterol(TC), triglyceride(TG), high density lipoprotein(HDL), PG I/II ratio, complication with hypertensive nephropathy, complication with retinopathy of the two groups were compared. Results The serum TG(t=3.264) and TC(t=3.853) of the Hp infection group were significantly higher than those of the control group(both P<0.05). And PG I/II ratio(t=-5.159) was significantly lower than that of the control group(P<0.05). The PG I/II ratio of the patients complicated with hypertensive nephropathy or retinopathy was significantly lower than that of the patients without the complication(t=2.754, 2.963, 3.022, 3.267, P<0.05) Area under the curve(AUCs) of PG I/II ratio in the diagnosis of the complication with hypertensive nephropathy and retinopathy of the patients hypertension were 0.774 and 0.883, respectively, which are significantly different(P<0.05). Conclusions The infection of Hp can lead to a significantly decreased PG I/II ratio in the patients with hypertension. This index(PG I / II ratio)can act as a indicator of complications with hypertension nephropathy and retinopathy. The index has a high diagnosis efficiency, which can be used as an auxiliary for early diagnosis.
出处
《慢性病学杂志》
2016年第2期158-161,共4页
Chronic Pathematology Journal
