摘要
目的:探讨血清胃蛋白酶原亚型(PG-Ⅰ,PG-Ⅱ)水平和PG-Ⅰ/PG-Ⅱ比值对慢性萎缩性胃炎(CAG)的临床应用价值。方法:使用酶联免疫吸附实验(ELISA)检测196例CAG患者和35例正常人血清PG-Ⅰ和PG-Ⅱ水平及PG-Ⅰ/PG-Ⅱ比值的变化。结果:CAG组血清PG-Ⅰ水平明显低于正常对照组,差异有统计学意义(P<0.05)。血清PG-Ⅰ水平随病情进展明显降低,各组间比较差异有统计学意义(P<0.05)。PG-Ⅰ/PG-Ⅱ比值的变化与血清PG-Ⅰ水平变化呈正相关。CAG组血清PG-Ⅱ水平略高于正常对照组,差异无统计学意义(P>0.05)。幽门螺杆菌(Hp)阳性CAG组与Hp阴性CAG组血清PG-Ⅰ和PG-Ⅱ水平及PG-Ⅰ/PG-Ⅱ比值基本一致,统计分析,差异无统计学意义(P>0.05)。结论:血清PG-Ⅰ和PG-Ⅰ/PG-Ⅱ比值的降低,是辅助诊断CAG的一项较好的血清学指标,适于人群筛查及胃镜检查禁忌者。
Objective ：To explore the clinical effect of pepsinogen - I （PG - I ）,pepsinogen - （PG - ~ ） and PG - I /PG - K in serum of patients with chronic atrophic gastritis（CAG）. Methods .. The levels of PG - I and PG - in serum of 196 cases of CAG and 35 cases of normal controls were measured by enzyme-linked immunosorbent assay （ELISA）. Results ..The serum PG - I levels of CAG group of patients were lower notable compared with that o~ the normal control group and with significant difference（P^0. 05）. The levels of PG - I in serum of patients with CAG were decreased remarkably alone with disease progression and among the three groups of CAG with significant differ- ences（P^0. 05）. PG - I /PG - I ratio changes with levels of serum PG - I were positively correlated. The serum PG - lI levels of patients with CAG slightly higher than the normal control group and with no significant difference（P~ 0.05）. The levels of serum PG - I ,PG - 1T and PG - I /PG - ]~ ratio in patients with CAG of helicobacter pylori（Hp）- positive and Hp-negative group were roughly consistent and with no significant differense（P〉0.05）. Conclusion .. The decreasing of PG - I in serum and the ratio of PG - I /PG - 11 are a better serological markers suitable for population screening and endoscopy contraindications.
出处
《临床医药实践》
2012年第9期643-645,共3页
Proceeding of Clinical Medicine
关键词
胃蛋白酶原亚群
萎缩性胃炎
酶联免疫吸附实验
pepsinogen subtypes
chronic atrophic gastritis
enzyme-linked immunosorbent assay
