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泮托拉唑联合磷酸铝凝胶、阿莫西林治疗HP相关性萎缩性胃炎疗效观察 被引量:5

The effect of Trip Pantoprazole Sodium in Treating atrophic gastritis related HP on gastroscopic and pathological Changes
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摘要 目的观察泮托拉唑联合磷酸铝凝胶、阿莫西林治疗幽门螺旋杆菌(HP)相关性萎缩性胃炎(CAG)疗效。方法回顾性分析经胃镜、病理诊断及HP检测阳性确诊的萎缩性胃炎116例,随机分为治疗组58例和对照组58例,治疗组用泮托拉唑+磷酸铝凝胶+阿莫西林,对照组用奥美拉唑+阿莫西林+甲硝唑,两组均连续治疗2周。治疗结束后3个月再次复查胃镜及行病理学检查,比较治疗前后胃镜、病理及HP阴转率的改变并进行统计学分析。结果治疗组HP根除率及总有效率明显高于对照组,患者治疗后胃镜下黏膜炎症及胃黏膜萎缩、异型增生、肠上皮化生均明显减轻。结论 HP持续感染可使萎缩性胃炎及肠上皮化生持续存在,且明显增加萎缩性胃炎、肠上皮化生的发生率及严重程度,根除HP可使萎缩性胃炎和肠上皮化生程度明显减轻,甚至获得改善。泮托拉唑联合磷酸铝凝胶、阿莫西林治疗HP相关性萎缩性胃炎可发挥协同作用,提高疗效,显著改善CAG胃黏膜炎症及其萎缩程度。
出处 《首都医药》 2011年第2期32-33,共2页 Capital Medicine
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