摘要
目的探讨醋酸环丙孕酮联合二甲双胍对多囊卵巢综合征患者内分泌及代谢的影响。方法选取医院诊治的多囊卵巢综合征患者72例,随机分为观察组与对照组,各36例。观察组患者给予醋酸环丙孕酮联合二甲双胍治疗,对照组患者予醋酸环丙孕酮治疗。结果治疗后,两组患者血清黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)水平明显低于治疗前(P<0.05);观察组患者LH水平为(6.2±1.1)U/L,明显低于对照组的(8.9±1.4)U/L(P<0.05);观察组患者FSH水平为(4.8±1.0)U/L,明显低于对照组的(5.6±1.2)U/L(P<0.05);观察组患者T水平为(0.42±0.10)mmol/L,明显低于对照组的(0.80±0.15)mmol/L(P<0.05)。两组患者治疗后空腹血糖(FBG)与空腹胰岛素(FIN)水平均明显低于治疗前(P<0.05);观察组患者FBG为(2.38±0.41)mmol/L,明显低于对照组的(3.68±0.48)mmol/L(P<0.05);观察组患者FIN为(17.98±3.01)IU/L,明显低于对照组的(21.97±3.25)IU/L(P<0.05)。结论醋酸环丙孕酮联合二甲双胍对多囊卵巢综合征患者的内分泌及代谢具有积极影响,值得临床推广。
Objective To discuss the influence of cyproterone acetate combined with metformin on endocrinology and metabolism of pa-tients with polycystic ovary syndrome ( PCOS ) . Methods 72 cases of patients with PCOS in the hospital were selected and randomly di-vided into the control group and the observation group, 36 cases in each group. The observation group was given the treatment of cypro-terone acetate combined with metformin while the control group was given the treatment of cyproterone acetate only. Results The level of LH, FSH, T of the two groups after treatment was obviously lower than that before treatment ( P < 0. 05 ) . The level of LH after treat-ment was ( 6. 2 ± 1. 1 ) IU/L and it was obviously lower than(8. 9 ± 1. 4)IU/L of the control group ( P < 0. 05 ) . The level of FSH after treatment was (4. 8 ± 1. 0)IU/L and it was obviously lower than(5. 6 ± 1. 2)IU/L of the control group( P < 0. 05). The level of T after treatment was ( 0. 42 ± 0. 10 ) mmol/L and it was obviously lower than(0. 80 ± 0. 15)mmol/L of the control group ( P < 0. 05 ) . The level of FBG after treatment was ( 2. 38 ± 0. 41 ) mmol/L and it was obviously lower than (3. 68 ± 0. 48)mmol/L of the control group(P < 0.05).The level of FIN after treatment was (17.98±3.01)IU/L and it was obviously lower than(21.97±3.25)IU/L of the control group ( P < 0. 05 ) . Conclusion Cyproterone acetate combined with metformin has a significant effect on endocrinology and metabolism of the patients with PCOS and it deserves clinical promotion.
出处
《中国药业》
CAS
2015年第21期80-81,共2页
China Pharmaceuticals
关键词
醋酸环丙孕酮
二甲双胍
多囊卵巢综合征
内分泌
代谢
cyproterone acetate
metformin
polycystic ovary syndrome
endocrinology
metabolism
