摘要
目的:观察肥胖型多囊卵巢综合征(PCOS)患者血清炎症因子的变化,探讨二甲双胍干预后的临床效果。方法:入选63例PCOS患者根据体重指数(BMI)分为肥胖型PCOS(BMI≥25 kg/m2)30例和非肥胖型PCOS(BMI<25 kg/m2)33例;另入选62例同期年龄相匹配的非PCOS育龄妇女为对照组,根据BMI分为肥胖对照组(BMI≥25 kg/m2)30例和正常对照组(BMI<25 kg/m2)32例。检测各组血清卵泡刺激素(FSH)、黄体生成素(LH)、泌乳素(PRL)、雌二醇(E2)、睾酮(T)和炎症因子高敏C反应蛋白(hsCRP)、肿瘤坏死因子-α(TNF-α)水平的变化。肥胖型PCOS患者给予二甲双胍干预12周,观察上述血清指标治疗后的变化。结果:与对照组比较,PCOS患者T、hsCRP和TNF-α水平升高,肥胖型PCOS高于非肥胖型PCOS,非肥胖型PCOS又高于肥胖对照组,而肥胖对照组高于正常对照组(均P<0.05)。经二甲双胍治疗12周后,肥胖型PCOS患者血清T、hsCRP和TNF-α水平明显下降(均P<0.05)。结论:肥胖型PCOS患者血清炎症因子水平升高,二甲双胍可降低肥胖型PCOS患者血清炎症因子水平。
Objective： To observe the changes of serum inflammatory factors in obese patients with polycystic ovary syndrome （P- COS） , explore the clinical efficacy after metformin intervention. Methods： 63 patients with PCOS were selected, then they were divided into obese PCOS group （BMI ≥25 kg/m2, 30 patients） and nonobese PCOS group （BMI 〈 25 kg/m2, 33 patients） . 62 age matched women of childbearing age without PCOS at the same time were selected as control group, then they were divided into obese control group （ BMI ≥ 25 kg/m2 ,30 patients） and normal control group （BMI 〈25 kg/m2, 32 patients） . The changes of serum levels of follicle stimulating hormone （ FSH）, prolactin, estradiol, testosterone and high sensitive C - reactive protein, tumor necrosis factor - a （ TNF - a） in the four groups were detected. The patients in obese PCOS group were treated with metformin for 12 weeks, the changes of above - mentioned indexes after treatment were observed. Results： Compared with control group, the levels of testosterone, high sensitive C - reactive protein and TNF - a in patients with PCOS increased, the levels of above - mentioned indexes in obese PCOS group were higher than those in non - obese P- COS group, the levels of above - mentioned indexes in non - obese PCOS group were higher than those in obese control group, and the levels of above - mentioned indexes in obese control group were higher than those in normal control group （ all P 〈 0. 05） . After treated with metformin for 12 weeks, the serum levels of testosterone, high sensitive C - reactive protein and TNF - a in obese PCOS group decreased significantly （ all P 〈 0. 05 ） . Conclusion： The serum levels of inflammatory factors increase in the obese patients with PCOS, metformin can reduce the serum levels of inflammatory factors in the obese patients with PCOS.
出处
《中国妇幼保健》
CAS
北大核心
2011年第25期3878-3881,共4页
Maternal and Child Health Care of China
关键词
肥胖
多囊卵巢综合征
高敏C反应蛋白
肿瘤坏死因子-A
二甲双胍
Obesity
Polycystic ovary syndrome
High sensitive C - reactive protein
Tumor necrosis factor - a
Metformin
