摘要
目的:探讨干扰素栓配合派特灵治疗宫颈上皮内瘤变(CIN)Ⅰ、Ⅱ级的疗效。方法:收治病理学诊断为CINⅠ级和CINⅡ级患者120人,随机分为两组,观察组60例,其中人乳头瘤病毒HPV高危亚型感染55例,给于干扰素栓加派特灵进行治疗;对照组60例,其中HPV高危亚型感染52例,患者仅进行观察不做治疗。两组于观察组用药结束3个月后均进行TCT和HPV复查。结果:应用干扰素栓加派特灵治疗3个疗程后,治疗组52例(86.7%)CIN转阴;对照组19例(31.7%)CIN转阴。两组治疗CIN的有效性相比差异有统计学意义(P<0.01)。应用干扰素栓加派特灵治疗后,观察组49例(81.7%)HPV高危亚型转为阴性,对照组19例(31.7%)HPV高危亚型转阴,两组相比差异具有统计学意义(P<0.01)。结论:应用干扰素栓加派特灵治疗CINⅠ级和CINⅡ级是安全有效的,为临床处理提供了新思路。
Objective:To investigate the effect interferon combined with Patling treatment of cervical intraepithelial neoplasia gradeⅠ、Ⅱ.Methods:From November 2010 to December 2012,120 patients admitted pathological diagnosis of CINⅠ and CINⅡ grade,were randomly divided into two groups:observation group,60 cases,including 55 cases with high-risk HPV subtypes of human papillomavirus infection,treat with interferon combined Patling;control group of 60 patients,including 52 cases with high-risk subtypes of HPV infection,patients were only observed but no treatment.three months later at end of the observation group treatment,two groups of patients were carried TCT medication and HPV review.Results:After application of interferon deployed Trane 3 courses of treatment,the treatment group 52 cases(86.7%)CIN negative;the control group 19 cases(31.7%)CIN negative.CIN effectiveness was statistically significant(P<0.01)in two compared group.In observation group 49 cases(81.7%)HPV high-risk subtypes became negative,in control group 19 cases(31.7%)HPV high-risk subtypes negative,the difference was statistically significante in two groups(P<0.01).Conclusion:interferon combined with Patling treatment grade CINⅠ and CINⅡ level is safe and effective,and providing new ideas for clinical treatment.
关键词
干扰素栓
派特灵
宫颈上皮内瘤变
Interferon
PatLing
Cervical intraepithelial neoplasia
