摘要
目的探讨派特灵治疗已婚未育妇女宫颈上皮内瘤变I级（CINI级）的疗效。方法回顾性分析浙江省诸暨市人民医院妇科就诊的185例病理学诊断为CINI级的已婚未育病例的病例资料，分为治疗组（100例）和对照组（85例）。派特灵给药3d停药4d为1个疗程，共4个疗程，患者用药结束后3个月复查宫颈刮片（TCT）及人乳头瘤病毒（HPV）。对照组确诊后3个月复查TCT和HPV。分析比较两组预后。结果人组时，治疗组平均（27．87＋3．91）岁，HPV阳性率为88．0％（88／100），对照组平均年龄（28．21±3．12）岁，HPV阳性率为83．5％（71／85），两组比较差异无统计学意义（t=-0．7，x2=0.4，P〉0．05）。随访结束时，治疗组CIN总体治愈率为81．0％（81／100），HPV转阴率78．4％（69／88）；对照组CIN总体治愈率28．2％（24／85），HPV转阴率36．6％（26／71）。两组相比差异均有统计学意义（x2=52．1、28．5，P〈0．01）。治疗组和对照组随访结束时TCT和HPV均阳性的患者比例差异有统计学意义（18．0％：49．4％，x2=25．8，P〈0．01）；两组治愈率差异无统计学意义（11．1％：7．1％，x2=o．3，P〉0．05）；治疗组TCT阳性和HPV阴性者中治愈率为94．3％（50／53），对照组为18．5％（5／27），两组比较差异有统计学意义仅毛50．7，P〈0．01）。用药期间，患者无明显不良反应。结论派特灵治疗能显著改善CINI级患者的预后，但在治疗后TCT及HPV仍阳性的患者中治愈率较低。
Objective To evaluate the efficacy of paiteling for cervical intraepithelial neoplasia grade I （CIN I ） treatment on married non pregnant women. Methods The data of 185 married non pregnant cases whose clinic pathological diagnosis were CIN I from Zhuji People＇s Hospital of Zhejiang were retrospectively analyzed. All the eases were divided into the treatment group （100 cases ）and control group （85 cases ）, according to whether they accept paiteling treatment. The treatment group recived paiteling for 3 days withdrawal 4 days as a course,and a total of 4 courses. All patients get cervical scraping smear （TCT）and human papillomavirus （HPV） test 3 months later. Prognostic results were evaluated. Results Before the treatment, cases in treatment group aged （27.87＋3.91） years old, the positive rate of HPV was 88.0% （88/100）; cases in control group were （28.21_＋3.12） years old, the positive rate of HPV was 83.5% （71/85）.There were no significant difference betweens the two groups （t=-0.7, X2= 0.4, P〉O.05 ）. At the end of follow up ,the CIN total cure rates of treatment group and control group were 81.0%（81/100） and 28.2% （24/85）, and the HPV negative rates in two group were 78.4% （69/88）and 36.6% （26/71）, and there were significant differences （x2=52.1, 28.5, P〈O.O1 ）. Between the treatment and control group, there were statistically significant differences about the proportion of patients who were positive for HPV and TCT at the end of follow up （18.0%：49.4%,X2 =25.8 ,P〈0.O1 ）, and no significant difference between the cure rates of two groups（11.1%：7.1%,x2=0.3, P〉O.05）; the cure rates of the patients with TCT-positive and HPV-nega- tive were 94.3% and 18.5% （x2= 50.7, P〈0.01）. There were no adverse reactions during drug treatment. Conclu- sions Paiteling can significantly improve the prognosis of patients with CIN I, but the cure rate of cases with TCT and HPV both positive after treatment is still low.
出处
《国际流行病学传染病学杂志》
CAS
2013年第6期383-386,共4页
International Journal of Epidemiology and Infectious Disease
关键词
宫颈上皮内瘤样病变
人乳头瘤病毒
派特灵
Cervical intraepithelial neoplasia
Human papillomavirus
Paiteling
