摘要
整合素作为细胞黏附受体家族成员,通过双向变构调节信号转导,介导细胞与细胞间以及细胞与细胞外基质间的黏附,并与细胞因子相互作用,参与调节胰腺癌细胞的增殖、凋亡、侵袭、迁移等生物学行为。以整合素为靶点的细胞学和动物研究表明,靶向整合素能有效提高胰腺癌的早期诊断率和药物治疗效果,这些发现为胰腺癌的临床诊治开辟了新的研究途径和发展方向。
Integrins are a family of cell adhesion receptors that mediate cell-cell and cell-extracellular matrix adhesion, and interact with cytokines through a bidirectional signal transduction,thus regulating the biological behavior of pancreatic cancer cells,such as proliferation,apoptosis,invasion,and migration etc. Molecular and animal studies indicated that integrins targeted methods might benefit the early diagnosis and drug therapy of pancreatic cancer,which offered a new approach for the study of diagnosis and treatment of pancreatic cancer.
出处
《胃肠病学》
2014年第7期436-438,共3页
Chinese Journal of Gastroenterology
关键词
整合素类
胰腺肿瘤
信号传导
Integrins
Pancreatic Neoplasms
Signal Transduction
