摘要
淋巴管对实体瘤的转移起着重要作用 ,目前研究表明 ,淋巴管生成因子 (VEGF C和VEGF D)可通过激活其位于淋巴管内皮细胞上的受体 (VEGFR 3)促进肿瘤内淋巴管生成 ,进而增加淋巴结转移率。同时 ,阻断VEGFR 3信号通道可抑制肿瘤淋巴管生成及淋巴结转移 ,因此 ,抗肿瘤淋巴管生成有望成为肿瘤转移抑制治疗的一条新途径。
Lymphatic vessels are important for the spread of solid tumors, and recent researches indicated that lymphangiogenic factors(VEGF C and VEGF D)could stimulate lymphangiogenesis in tumors by activating their receptors on the lymphatic endothelial cells, then enhance the incidence of lymph node metastasis. In addition, inhibition of VEGFR 3 signaling could suppress tumor lymphangiogenesis and metastasis to lymph nodes, thus, inhibition of lymphangiogenesis can be expected to be a new method of blocking tumor metastasis.
出处
《中国癌症杂志》
CAS
CSCD
2003年第5期475-479,共5页
China Oncology
