摘要
目的 观察骨松宝的抗骨质疏松作用。方法 用摘除大鼠双侧卵巢的方法造成大鼠实验性骨质疏松,观察骨松宝对骨质疏松模型大鼠的骨形态计量指标、血液生化指标及每日尿中钙、磷排出量的影响。结果 与对照组相比,骨松宝各组大鼠的骨小梁平均宽度、相对骨体积、骨皮质平均厚度、骨钙、股骨头和股骨干平均灰度明显增高,使其血清降钙素(CT)和血Ca水平明显增加,骨松宝高、中剂量可使其骨小梁单位面积骨细胞数明显增加。并可明显降低血清ALP水平,使每日尿中排钙量明显减少。结论 骨松宝对去卵巢所致大鼠过高的骨转换具有明显的抑制作用,并能提高骨再建能力,对去卵巢大鼠骨质疏松有明显的对抗作用。
Objective To observe the therapeutic effect of Gusongbao capsule for osteoporosis. Methods Experimental osteoporosis rat models were established by extirpation of bilateral ovaries of female rats. Bone morphological indexes, blood biochemical indexes, and daily output of calcium and phosphorus in urine in the Gusongbao treatment group and control group were determined. Results Compared with the control, the average width of bone trabecula, relative bone volume, average thickness of bone cortex, bone calcium, and the average gray degree of femoral head and femoral shaft were high, and the serum calcitonin (CT) and blood calcium increased markedly in the treatment group. High-dose and moderate-dose Gusongbao increased number of osteocytes in per unit area of bone trabecula, decreased serum alkaline phosphatase (ALP) level and reduced the daily output of urine calcium. Conclusion Gusongbao capsule can obviously inhibit the excessive bone transformation and promote the re-construction of bone and exerts an antagonistic effect on osteoporosis in ovariectomized rats.
出处
《中药新药与临床药理》
CAS
CSCD
2003年第5期317-318,共2页
Traditional Chinese Drug Research and Clinical Pharmacology
