摘要
目的:探讨益气活血壮骨方对去势大鼠骨形态学的影响。方法:将45只6月龄雌性SD大鼠随机分为5组:假手术组(A组)、模型组(B组)、益气活血壮骨方组(C组)、乐力胶囊组(D组)和骨松宝组(E组),每组9只。假手术组仅开腹缝合,其余4组做卵巢切除术。术后4周,A、B组大鼠以生理盐水灌胃(10 mL·kg-1),C组大鼠以益气活血壮骨方灌胃(9.6 g·kg-1),D组大鼠以乐力胶囊灌胃(0.15 g·kg-1),E组大鼠以骨松宝灌胃(8 g.kg-1),每天1次,连续给药12周。12周后处死大鼠,观察各组大鼠骨小梁平均宽度、相对骨体积、单位面积骨小梁骨细胞数、平均骨皮质厚度及股骨头平均灰度。结果:①A、C、D、E组大鼠的骨小梁平均宽度、相对骨体积、单位面积骨小梁骨细胞数、平均骨皮质厚度及股骨头平均灰度均高于B组,差异有统计学意义(P<0.05);②A、C组各项实验指标均高于D、E组,差异有统计学意义(P<0.05);③A、C组各项指标差异无统计学意义(P>0.05),D、E组各项指标差异无统计学意义(P>0.05)。结论:益气活血壮骨方能提高去势大鼠骨小梁平均宽度、相对骨体积、单位面积骨小梁骨细胞数、平均骨皮质厚度及股骨头平均灰度,并能使其接近正常水平,疗效优于乐力胶囊和骨松宝。
Objective：To explore the effect of Yiqihuoxue Zhuanggu（YQHXZG） decoction（益气活血壮骨方）on bone morphology in castrated rats.Methods：45 rats were randomly divided into sham-operated group（group A）,model group（group B）,YQHXZG decoction group（group C）,LELI（compound calcium amino acid chelate） capsules group（group D） and GUSONGBAO（a kind of traditional Chinese medicine） group（group E）,9 cases in each group.The cases in group A were administrated with sham-operation only,while those in other groups were administrated with oophorectomy.4 weeks after operation,rats in group A and group B were lavaged with physiological saline（10 mL·kg-1）,rats in group C were lavaged with YQHXZG decoction（9.6 g·kg-1）,rats in group D were lavaged with LELI capsules（0.15 g·kg-1）and rats in group E were lavaged with GUSONGBAO（8 g·kg-1）,once a day for consecutive 12 weeks.12 weeks later,all the rats were sacrificed.The average width of the bone trabecula,relative bone volume,cell population of bone trabecula in unit area,the average thickness of cortical bone and the average gray scale of femoral head of the rats were measured.Results：①The average width of the bone trabecula,relative bone volume,cell population of bone trabecula in unit area,the average thickness of cortical bone and the average gray scale of femoral head of the rats in group A,group C,group D and group E were higher than those of the rats in group B（P0.05）.②Every experimental index of group A and group C was higher than that of group D and group E（P0.05）.③There was no statistical difference in every experimental index between group A and group C（P0.05）,and there was no statistical difference in every experimental index between groupD and group E（P0.05）.Conclusion：Yiqihuoxue Zhuanggu decoction（益气活血壮骨方）,which performs better than LELI capsules and GUSONGBAO,can elevate the following index as the average width of the bone trabecula,relative bone volume,cell populatio
出处
《中医正骨》
2011年第3期3-5,共3页
The Journal of Traditional Chinese Orthopedics and Traumatology
基金
国家教育部重点学科项目
上海市重点学科项目(第二期)(T0303)
关键词
骨质疏松
益气活血
补肾养血
骨形态学
Osteoporosis
Reinforcing QI activat blood
Reinforcing kidney nour blood
Bone Morphology
