摘要
目的探究血清鳞状细胞癌相关抗原(squamous cell carcinoma antigen,SCC-Ag)检测在超早期肺癌中的诊断价值。方法选取81例初治的超早期肺癌患者为实验组,选取同期体检的90例健康体检者为对照组,分别对2组研究对象中性粒细胞计数、淋巴细胞计数及血清SCC-Ag水平进行测定并进行对比,而后以病理检查结果作为金标准,对SCC-Ag检查的特异性、敏感度、假阳性率及假阴性率进行测定,最后对实验组患者的血清癌胚抗原(CEA)进行测定,并就SCC-Ag水平与CEA水平的相关性进行分析。结果经对比,实验组中性粒细胞计数及SCC-Ag水平显著高于对照组,淋巴细胞计数显著低于对照组,对比差异具有统计学意义(P <0. 05); ROC分析发现,SCC-Ag检测的灵敏度为33. 1%,特异度为87. 3%,假阳性率为67. 5%,假阴性率为71. 9%。相关性分析可以发现,实验组患者血清SCC-Ag水平与其CEA水平成正相关关系(γ=0. 682,P <0. 05)。结论 SCC-Ag检测能够较为准确地反映超早期肺癌患者的病情,值得进行临床推广。
Objective To investigate the diagnostic value of serum squamous cell carcinoma antigen(SCC-Ag)in ultraearly stage lung cancer.Methods 81 cases of ultra-early lung cancer patients for the experimental group,select the same period in our hospital for 90 cases of physical examination as a control group,respectively,two groups The neutrophil count,lymphocyte count and serum SCC-Ag level were measured and compared.The specificity,sensitivity,false positive rate and false negative rate of SCC-Ag Finally,the serum CEA in the experimental group was measured and the correlation between the level of SCC-Ag and CEA was analyzed.Results Compared with the control group,the neutrophil count and SCC-Ag level in the experimental group were significantly lower than those in the control group(P<0.05);ROC analysis showed that,The sensitivity of SCC-Ag assay was 33.1%,the specificity was 87.3%,the false positive rate was 67.5%and the false negative rate was 71.9%.Correlation analysis showed that serum SCC-Ag level was positively correlated with CEA level Contact(γ=0.682,P<0.05).Conclusion The SCC-Ag test can accurately reflect the condition of patients with ultra-early lung cancer and is worthy of clinical promotion.
作者
安翠红
宁文君
马彩虹
AN Cuihong;NING Wenjun;MA Caihong(Xi’an Daxing Hospital,Xi’an,710016)
出处
《实用癌症杂志》
2019年第4期600-602,共3页
The Practical Journal of Cancer
