摘要
目的观察血清癌胚抗原(CEA)、鳞状上皮细胞癌抗原(SCC-Ag)水平联合检测在早期子宫颈癌诊断中的应用价值。方法选取2016年8月~2018年2月本院37例早期子宫颈癌患者作为子宫颈癌组,选取同期本院37例良性子宫疾病患者作为对照组,采用酶联免疫法测定血清CEA水平,采用磁分离酶联免疫法测定血清SCC-Ag水平。结果子宫颈癌组血清CEA、SCC-Ag水平高于对照组(P <0.05);Ⅰ期/Ⅱ期子宫颈癌患者血清CEA、SCC-Ag检测阳性率低于Ⅲ期/Ⅳ期;鳞癌血清CEA检测阳性率低于腺癌,SCC-Ag检测阳性率高于腺癌(P <0.05);血清CEA、SCC-Ag联合检测敏感度、诊断准确度较血清CEA、SCC-Ag单独检测高(P <0.05)。结论血清CEA、SCCAg水平与子宫颈癌发生、发展有密切关系,其水平检测在早期子宫颈癌临床分期诊断中具有重要价值,二者联合可提高诊断敏感度与准确度,其中SCC-Ag在子宫颈鳞癌诊断中价值较高。
Objective To observe the value of combined detection of serum carcinoembryonic antigen (CEA) and squamous cell carcinoma antigen (SCC-Ag) levels in the diagnosis of early cervical cancer. Methods 37 patients with early cervical cancer in our hospita from August 2016 to February 2018 were enrolled in the cervical cancer group. 37 patients with benign uterine disease in our hospital were selected as the control group. Serum CEA levels were determined by enzyme-linked immunosorbent assay. Serum SCC-Ag levels were determined by magnetic separation enzyme-linked immunosorbent assay. Results The levels of serum CEA and SCC-Ag in cervical cancer group were higher than those in the control group (P < 0.05). The positive rate of serum CEA and SCC-Ag in stage I/II cervical cancer patients was lower than that in stage III/IV. The positive rate of serum CEA in squamous cell carcinoma was lower than that in adenocarcinoma and the positive rate of SCC-Ag was higher than that of adenocarcinoma (P < 0.05). The sensitivity of combined detection of CEA and SCC-Ag was higher than that of serum CEA and SCC-Ag alone.(P < 0.05). Conclusion The levels of serum CEA and SCC-Ag are closely related to the occurrence and development of cervical cancer. The detection of serum levels is of great value in the clinical diagnosis of early stage cervical cancer. The combination of the two can improve the sensitivity and accuracy of diagnosis. SCC-Ag is especially of high value in the diagnosis of cervical squamous cell carcinoma.
作者
郑艳冰
ZHENG Yan-bing(The First Affiliated Hospital of Nanyang Medical College, Nanyang, Henan, 473000, China)
出处
《临床研究》
2019年第7期136-138,共3页
Clinical Research
关键词
癌胚抗原
鳞状上皮细胞癌抗原
子宫颈癌
阳性检出率
carcinoembryonic antigen
squamous cell carcinoma antigen
cervical cancer
positive detection rate
