摘要
目的探讨Dukes B期大肠癌患者根治性术后辅助化疗的疗效及安全性。方法 Dukes B期大肠癌患者120例,按随机数字表法分为2组,单纯手术组60例和联合组60例。联合组:在接受根治性手术治疗的基础上,辅助化疗。化疗方案:甲酰四氢叶酸钙每日300 mg/m2静脉注射(2 h注射完毕)+5-氟尿嘧啶每日600 mg/m2持续静脉给药24 h,连续2天。2~3周为1个疗程,5个疗程为1个周期。单纯手术组:仅接受根治性手术治疗,术后不辅助化疗。记录患者3年无瘤生存率以及5年生存率。结果单纯手术组和联合组Dukes B1期、Dukes B2期、Dukes B3期分别占11%、20%、19%和14%、21%、15%,差异无统计学意义(χ2=0.003、0.001、0.002,P>0.05);单纯手术组和联合组3年无瘤生存率以及5年生存率分别为84%、92%和68%、80%,差异有统计学意义(χ2=6.2、5.7,P<0.05)。结论 Dukes B期大肠癌患者根治性手术后辅助5-氟尿嘧啶和甲酰四氢叶酸钙化疗,能够明显提高3年无瘤生存率以及5年生存率,值得临床推广。
Objective To investigate the efficacy and safety of adjuvant chemotherapy for Dukes B colorectal cancer after radical surgery. Methods 120 cases of Dukes B colorectal cancer,according to the random number table,were divided into simple operation group and combined group,each with 60 cases. Combined group received radical surgery and chemotherapy regimen of formyl leucovorin 300 mg daily intravenous injection daily( finished in 2 hours) and 600 mg of 5-fluorouracil continuous intravenous administration 24 h for 2 days. 2 ~ 3 weeks was 1 course,5 courses was 1 cycle. The simple operation group received radical operation only,and no chemotherapy regimen was received after operation. 3-year disease-free survival rate and 5- year survival rate were recorded. Results Simple operation group and combined group Dukes B stage,Dukes B2 stage,Dukes B3 stage were 11%,20%,19%; 14%,21%,15%,respectively,the difference was not statistically significant( chi square χ2= 0. 003,0. 001,0. 002,P > 0. 05); and the surgery group and combined group 3-year disease- free survival rates and 5-year survival rates were 84% and 92%,68% and 80%,respectively,the difference was statistically significant( chi square χ2= 6. 2,5. 7,P <0. 05). Conclusion Dukes B colorectal cancer after radical surgery received 5-fluorouracil and calcium folinate adjuvant chemotherapy,it can significantly improve 3-year disease-free survival rate and 5-year survival rate,and it is worthy of clinical application.
出处
《实用癌症杂志》
2015年第6期860-861,864,共3页
The Practical Journal of Cancer
